Anti-DYNLL1/PIN抗体(ab189854)
Key features and details
- Rabbit polyclonal to DYNLL1/PIN
- Suitable for: WB
- Reacts with: Mouse, Human
- Isotype: IgG
概述
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产品名称
Anti-DYNLL1/PIN抗体
参阅全部 DYNLL1/PIN 一抗 -
描述
兔多克隆抗体to DYNLL1/PIN -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Mouse, Human
预测可用于: Rabbit, Cow, Drosophila melanogaster, Cynomolgus monkey -
免疫原
Recombinant full length protein corresponding to Human DYNLL1/PIN aa 1 to the C-terminus.
Database link: P63167 -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol, 49% PBS -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
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Related Products
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab189854于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/500 - 1/2000. Predicted molecular weight: 10 kDa.
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说明 |
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WB
1/500 - 1/2000. Predicted molecular weight: 10 kDa. |
靶标
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功能
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
Binds and inhibits the catalytic activity of neuronal nitric oxide synthase.
Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1.
Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity. -
组织特异性
Ubiquitous. -
序列相似性
Belongs to the dynein light chain family. -
翻译后修饰
Phosphorylation at Ser-88 appears to control the dimer-monomer transition. According to PubMed:15193260, it is phosphorylated at Ser-88 by PAK1, however, according to PubMed:18650427, the DYNLL1 dimer is not accessible for PAK1 and the phosphorylation could not be demonstrated in vitro. -
细胞定位
Cytoplasm, cytoskeleton. Nucleus. Mitochondrion. Upon induction of apoptosis translocates together with BCL2L11 to mitochondria. - Information by UniProt
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数据库链接
- Entrez Gene: 404151 Cow
- Entrez Gene: 101866391 Cynomolgus monkey
- Entrez Gene: 31405 Drosophila melanogaster
- Entrez Gene: 8655 Human
- Entrez Gene: 56455 Mouse
- Entrez Gene: 100008650 Rabbit
- Omim: 601562 Human
- SwissProt: P61285 Cow
see all -
别名
- 8 kDa dynein light chain antibody
- 8kDLC antibody
- Cytoplasmic dynein light polypeptide antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab189854 尚未被引用在任何文献中。