Anti-Dynein intermediate chain 2抗体(ab108237)

概述

  • 产品名称Anti-Dynein intermediate chain 2抗体
    参阅全部 Dynein intermediate chain 2 一抗
  • 描述
    兔多克隆抗体to Dynein intermediate chain 2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 71-120 (TRGVNHVEGG WPKDVNPLEL EQTIRFRKKV EKDENYVNAI MQLGSIMEHC) of Human Dynein intermediate chain 2 (NP_075462).

  • 阳性对照
    • PANC1 cell lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab108237 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 69 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Part of the dynein complex of respiratory cilia.
  • 组织特异性Highly expressed in trachea and testis.
  • 疾病相关Defects in DNAI2 are the cause of primary ciliary dyskinesia type 9 (CILD9) [MIM:612444]. CILD is an autosomal recessive disorder characterized by axonemal abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit situs inversus, due to dysfunction of monocilia at the embryonic node and randomization of left-right body asymmetry. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.
  • 序列相似性Belongs to the dynein intermediate chain family.
    Contains 5 WD repeats.
  • 细胞定位Cytoplasm > cytoskeleton > cilium axoneme.
  • Information by UniProt
  • 数据库链接
  • 别名
    • axonemal antibody
    • Axonemal dynein intermediate chain 2 antibody
    • CILD9 antibody
    • DNAI 2 antibody
    • Dnai2 antibody
    • DNAI2_HUMAN antibody
    • Dynein axonemal intermediate chain 2 antibody
    • Dynein axonemal intermediate polypeptide 2 antibody
    • Dynein intermediate chain 2 antibody
    • Dynein intermediate chain 2 axonemal antibody
    see all

Anti-Dynein intermediate chain 2 antibody 图像

  • Anti-Dynein intermediate chain 2 antibody (ab108237) at 1 µg/ml + PANC1 cell lysate at 10 µg

    Predicted band size : 69 kDa

Anti-Dynein intermediate chain 2 antibody (ab108237)参考文献

ab108237 has not yet been referenced specifically in any publications.

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