概述

  • 产品名称Anti-DYNC1I2抗体
    参阅全部 DYNC1I2 一抗
  • 描述
    兔多克隆抗体to DYNC1I2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow, Zebrafish
  • 免疫原

    Recombinant protein fragment, corresponding to a region within amino acids 129 and 376 of Human DYNC1I2

  • 阳性对照
    • HeLa whole cell lysate

性能

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应用

Our Abpromise guarantee covers the use of ab96288 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 71 kDa.

靶标

  • 功能Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes.
  • 序列相似性Belongs to the dynein intermediate chain family.
    Contains 7 WD repeats.
  • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR. The phosphorylation status of Ser-90 appears to be involved in dynactin-dependent target binding.
  • 细胞定位Cytoplasm > cytoskeleton.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Cytoplasmic dynein 1 intermediate chain 2 antibody
    • Cytoplasmic dynein intermediate chain 2 antibody
    • cytosolic antibody
    • DC1I2_HUMAN antibody
    • DH IC 2 antibody
    • DH IC-2 antibody
    • DNCI2 antibody
    • DNCIC2 antibody
    • Dync1i2 antibody
    • Dynein intermediate chain 2 antibody
    • Dynein intermediate chain 2, cytosolic antibody
    • Dynein, cytoplasmic, intermediate polypeptide 2 antibody
    • IC2 antibody
    see all

Anti-DYNC1I2 antibody 图像

  • Anti-DYNC1I2 antibody (ab96288) at 1/1000 dilution + HeLa whole cell lysate at 30 µg

    Predicted band size : 71 kDa

Anti-DYNC1I2 antibody (ab96288)参考文献

This product has been referenced in:
  • Thinon E  et al. Global profiling of co- and post-translationally N-myristoylated proteomes in human cells. Nat Commun 5:4919 (2014). Read more (PubMed: 25255805) »

See 1 Publication for this product

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