概述

  • 产品名称Anti-Dynamin 2抗体
    参阅全部 Dynamin 2 一抗
  • 描述
    兔多克隆抗体to Dynamin 2
  • 经测试应用适用于: IPmore details
    不适用于: WB
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Cow, Pig, Chimpanzee, Rhesus monkey, Gorilla, Chinese Hamster, Orangutan, Elephant
  • 免疫原

    Synthetic peptide, corresponding to a region within amino acids 625-675 of Human Dynamin 2 (NP_001005360.1)

  • 阳性对照
    • HeLa cell lysates

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab124251 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP Use at 2-10 µg/mg of lysate.
  • 应用说明Is unsuitable for WB.
  • 靶标

    • 功能Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis.
    • 组织特异性Ubiquitously expressed.
    • 疾病相关Defects in DNM2 are a cause of centronuclear myopathy autosomal dominant (ADCNM) [MIM:160150]; also known as autosomal dominant myotubular myopathy. Centronuclear myopathies (CNMs) are congenital muscle disorders characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. CNMs comprise a wide spectrum of phenotypes, ranging from severe neonatal to mild late-onset familial forms. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.
      Defects in DNM2 are the cause of Charcot-Marie-Tooth disease dominant intermediate type B (CMTDIB) [MIM:606482]. Charcot-Marie-Tooth disease (CMT) is a clinically and genetically heterogeneous disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. CMTDIB is a form of Charcot-Marie-Tooth disease characterized by clinical and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec.
    • 序列相似性Belongs to the dynamin family.
      Contains 1 GED domain.
      Contains 1 PH domain.
    • 细胞定位Cytoplasm. Cytoplasm > cytoskeleton. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell junction > synapse. Microtubule-associated. Also found in the postsynaptic density of neuronal cells.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CMT2M antibody
      • CMTDI1 antibody
      • CMTDIB antibody
      • DI CMTB antibody
      • Dnm2 antibody
      • DYN II antibody
      • DYN2 antibody
      • DYN2_HUMAN antibody
      • Dynamin II antibody
      • Dynamin-2 antibody
      • Dynamin2 antibody
      • DynaminII antibody
      • DYNII antibody
      see all

    Anti-Dynamin 2 antibody 图像

    • An antibody to Dynamin 2 at 1 µg/ml, staining Dynamin 2 in HeLa whole cell lysate immunoprecipitated using ab124251 at 6 µg/mg lysate (1 mg/IP; 20% of IP loaded/lane). Detection: Chemiluminescence with an exposure time of 30 seconds.

    Anti-Dynamin 2 antibody (ab124251)参考文献

    ab124251 has not yet been referenced specifically in any publications.

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