概述

  • 产品名称
  • 描述
    兔多克隆抗体to DUSP1
  • 特异性
    ab61201 detects endogenous levels of total DUSP1 protein.
  • 经测试应用
    适用于: ICC/IF, WB, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to Human DUSP1 (C terminal). Immunogen in the range of aa 318-367
    Database link: P28562

  • 阳性对照
    • Jurkat cell extracts.

性能

应用

Our Abpromise guarantee covers the use of ab61201 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use at an assay dependent concentration. PubMed: 21771966
WB 1/500 - 1/1000. Detects a band of approximately 39 kDa (predicted molecular weight: 39 kDa).
IHC-P Use at an assay dependent concentration.

靶标

  • 功能
    Dual specificity phosphatase that dephosphorylates MAP kinase ERK2 on both 'Thr-183' and 'Tyr-185'.
  • 组织特异性
    Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney.
  • 序列相似性
    Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
    Contains 1 rhodanese domain.
    Contains 1 tyrosine-protein phosphatase domain.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CL 100 antibody
    • CL100 antibody
    • Dual Specificity Phosphatase 1 antibody
    • Dual specificity protein phosphatase 1 antibody
    • Dual specificity protein phosphatase hVH1 antibody
    • DUS1_HUMAN antibody
    • DUSP 1 antibody
    • Dusp1 antibody
    • HVH1 antibody
    • MAP kinase phosphatase 1 antibody
    • Mitogen-activated protein kinase phosphatase 1 antibody
    • MKP-1 antibody
    • MKP1 antibody
    • Protein tyrosine phosphatase CL100 antibody
    • Protein-tyrosine phosphatase CL100 antibody
    • PTPN10 antibody
    • Serine/threonine specific protein phosphatase antibody
    • VH1 antibody
    see all

图片

  • Immunohistochemical analysis of paraffin embedded human brain tissue labeling DUSP1 with ab61201. Rigth panel blocked with the synthesized peptide.

  • All lanes : Anti-DUSP1 antibody (ab61201) at 1/500 dilution

    Lane 1 : Jurkat cell extracts
    Lane 2 : Jurkat cell extracts with immunising peptide


    Predicted band size : 39 kDa
    Observed band size : 39 kDa

文献

This product has been referenced in:
  • Szelenyi ER & Urso ML Time-course analysis of injured skeletal muscle suggests a critical involvement of ERK1/2 signaling in the acute inflammatory response. Muscle Nerve 45:552-61 (2012). WB ; Mouse . Read more (PubMed: 22431089) »
  • Asrih M  et al. Role of ERK1/2 activation in microtubule stabilization and glucose transport in cardiomyocytes. Am J Physiol Endocrinol Metab 301:E836-43 (2011). ICC/IF ; Rat . Read more (PubMed: 21771966) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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