Anti-Dscam抗体(ab51974)

概述

  • 产品名称Anti-Dscam抗体
    参阅全部 Dscam 一抗
  • 描述
    山羊多克隆抗体to Dscam
  • 特异性This antibody is expected to recognise both reported isoforms.
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Rat, Dog
  • 免疫原

    Peptide with sequence CDSWDSAQRTKDVSPQ, from the internal region of the protein sequence (Human)

  • 阳性对照
    • NIH/3T3 cell lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

相关产品

应用

Our Abpromise guarantee covers the use of ab51974 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 2 - 6 µg/ml. Detects a band of approximately 170 kDa.

靶标

  • 功能Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies. Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. In spinal chord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding. Enhances netrin-induced phosphorylation of PAK1 and FYN. Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38.
  • 组织特异性Primarily expressed in brain.
  • 序列相似性Contains 6 fibronectin type-III domains.
    Contains 10 Ig-like C2-type (immunoglobulin-like) domains.
  • 结构域Ig-like C2-type domains 7 to 9 are sufficient for interaction with NTN1 and commissural axon outgrowth. The transmembrane domain is necessary for interaction with DCC.
  • 翻译后修饰Phosphorylated at tyrosine residues. Phosphorylation is enhanced by netrin.
  • 细胞定位Secreted and Cell membrane. Localized in the soma, cell membrane, axon and growth cone of dissociated commissural axons.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CHD2 42 antibody
    • CHD2 52 antibody
    • CHD2 antibody
    • Down syndrome cell adhesion molecule antibody
    • DSCAM antibody
    • DSCAM_HUMAN antibody
    • human CHD2-52 down syndrome cell adhesion molecule 2, 9 antibody
    • OTTHUMP00000109193 2 antibody
    • SD11109p antibody
    see all

Anti-Dscam antibody 图像

Anti-Dscam antibody (ab51974)参考文献

ab51974 has not yet been referenced specifically in any publications.

Product Wall

Abcam has not validated the combination of species/application used in this Abreview.
Application Immunohistochemistry (PFA fixed)
Sample Mouse Cell (Brain)
Specification Brain
Username

Dr. Minkyung Kim

Verified customer

提交于 Jun 04 2010

Thank you for your enquiry. This antibody has been tested in western blot, but unfortunately, we do not have any data on IP. For western blot, we recommend to use the antibody at a concentration of 1 - 3 µg/ml. Please note, that IP is not a guarant...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"