概述

  • 产品名称
    Anti-DsbA L抗体
  • 描述
    兔多克隆抗体to DsbA L
  • 特异性
    ab92819 is specific for the ~25 kDa DsbA-L protein in Western blots of 3T3-L1 adipocytes and mouse white and brown adipose tissue lysate samples.
  • 经测试应用
    适用于: WB, IHC-Frmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Recombinant full length Mouse DsbA L protein.

  • 阳性对照
    • 3T3-L1 adipocytes and Mouse white and brown adipose tissue lysate.

应用

Our Abpromise guarantee covers the use of ab92819 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/2000. Detects a band of approximately 25 kDa.
IHC-Fr Use at an assay dependent concentration.

靶标

  • 相关性
    Disulfide-bond-A oxidoreductase-like protein (DsbA-L, previously named as GST Kappa) is an adiponectin-interacting protein. DsbA-L is highly expressed in adipose tissue, and its expression level is negatively correlated with obesity in mice and humans. DsbA-L expression in 3T3-L1 adipocytes is stimulated by the insulin sensitizer rosiglitazone and inhibited by the inflammatory cytokine TNFalpha. Polymorphism of DsbA-L gene has recently been implicated in insulin secretion and body fat distribution. Overexpression of DsbA-L promotes adiponectin multimerization while suppressing DsbA-L expression by RNAi markedly and selectively reduces adiponectin levels and secretion in 3T3-L1 adipocytes. Recent studies identify DsbA-L as a key regulator for adiponectin biosynthesis.
  • 别名
    • DSBA like thioredoxin domain containing protein antibody

图片

  • Anti-DsbA L antibody (ab92819) at 1/2000 dilution + Mouse adipose tissue

文献

This product has been referenced in:
  • Jedrychowski MP  et al. Adiporedoxin, an upstream regulator of ER oxidative folding and protein secretion in adipocytes. Mol Metab 4:758-70 (2015). Read more (PubMed: 26629401) »
  • Fu Z  et al. Dietary ?-3 polyunsaturated fatty acids decrease retinal neovascularization by adipose-endoplasmic reticulum stress reduction to increase adiponectin. Am J Clin Nutr 101:879-88 (2015). Read more (PubMed: 25833984) »

See all 3 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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