概述

  • 产品名称DRB (Benzimidazole)
  • 描述
    Casein kinase II inhibitor
  • 别名
    • Benzimidazole
    • DiCl-RB
    • NSC 401575
  • 生物学描述Casein kinase II inhibitor (Ki values are 23 and 48 μM for CKII and CKI, respectively). Inhibitor of RNA polymerase II transcription in vitro and in vivo. Shown to inhibit cyclin C/CDK8 (IC50 = 17 μM) and cyclin H/CDK7/p38 (IC50 = 18 μM) signaling.
  • 纯度> 98%

性能

    DRB (Benzimidazole) (ab120939)参考文献

    This product has been referenced in:
    • Ye ZY  et al. Protein kinase CK2 increases glutamatergic input in the hypothalamus and sympathetic vasomotor tone in hypertension. J Neurosci 31:8271-9 (2011). Read more (PubMed: 21632948) »
    • Rickert P  et al. Cyclin C/CDK8 and cyclin H/CDK7/p36 are biochemically distinct CTD kinases. Oncogene 18:1093-102 (1999). Read more (PubMed: 10023686) »
    • Meggio F  et al. Ribofuranosyl-benzimidazole derivatives as inhibitors of casein kinase-2 and casein kinase-1. Eur J Biochem 187:89-94 (1990). Read more (PubMed: 2105215) »

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