Recombinant fusion protein DR6:Fc, corresponding to amino acids 42-335 of Human DR6.
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Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 µg/ml. ab18450-Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes.
Contains 1 death domain. Contains 4 TNFR-Cys repeats.
Tumor necrosis factor receptor superfamily member 21 antibody
Tumor necrosis factor receptor superfamily member 21 precursor antibody
Flow Cytometry - DR6 antibody [Luke-1] (ab17318)
Ab17318 at a concentration of 1 ug/ml used in mock transfecting (thin line) or transfecting (thick line) HEK 293T cells with an expression plasmid coding for the extracellular domain of human DR6 by Flow Cytometry.