Anti-DR6抗体[DR-6-04-EC] (ab14740)

概述

  • 产品名称Anti-DR6抗体[DR-6-04-EC]
    参阅全部 DR6 一抗
  • 描述
    小鼠单克隆抗体[DR-6-04-EC] to DR6
  • 特异性The antibody immunoprecipitates overexpressed DR6 from DR6-transfected HEK/293 cells but has not been tested on endogenous DR6 therefore we do not guarantee it will work on endogenous DR6.
  • 经测试应用适用于: Flow Cyt, IP, ICC/IFmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Fusion protein, corresponding to extracellular amino acids 42-335 of Human DR6, linked to the Fc portion of human IgG1.

  • 阳性对照
    • overexpressed DR6 from DR6-transfected HEK/293 cells.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: 15mM Sodium Azide
    Constituents: PBS, pH 7.4
  • Concentration information loading...
  • 纯度Protein A purified
  • 克隆单克隆
  • 克隆编号DR-6-04-EC
  • 同种型IgG1
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab14740 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use a concentration of 1 µg/ml. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
IP Use at an assay dependent concentration. Antibody immunoprecipitates overexpressed DR6 from DR6-transfected HEK/293 cells.
ICC/IF Use at an assay dependent concentration.

靶标

  • 功能May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
  • 组织特异性Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes.
  • 序列相似性Contains 1 death domain.
    Contains 4 TNFR-Cys repeats.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • TNFRSF 21 antibody
    • BM 018 antibody
    • BM018 antibody
    • CD358 antibody
    • Death receptor 6 antibody
    • DR 6 antibody
    • DR6 antibody
    • MGC31965 antibody
    • OTTHUMP00000039915 antibody
    • TNFR related death receptor 6 antibody
    • TNFRSF21 antibody
    • TNFRSF21 protein antibody
    • TNR21_HUMAN antibody
    • Tumor necrosis factor receptor superfamily member 21 antibody
    • Tumor necrosis factor receptor superfamily member 21 precursor antibody
    see all

Anti-DR6 antibody [DR-6-04-EC] 图像

  • ab14740 staining DR6 (green) in transiently transfected human Hela cells by ICC/IF. Nuclei were stained with DAPI (blue).

Anti-DR6 antibody [DR-6-04-EC] (ab14740)参考文献

ab14740 has not yet been referenced specifically in any publications.

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