概述

  • 产品名称Anti-DR6抗体
    参阅全部 DR6 一抗
  • 描述
    兔多克隆抗体to DR6
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    corresponding to amino acids 371-655 of Human DR6 (cytoplasmic domain).

  • 阳性对照
    • Daudi, HeLa, or Jurkat whole cell lysates.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度Protein G purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab47180 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 2 - 4 µg/ml. Detects a band of approximately 66 kDa (predicted molecular weight: 72 kDa).

靶标

  • 功能May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
  • 组织特异性Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes.
  • 序列相似性Contains 1 death domain.
    Contains 4 TNFR-Cys repeats.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • TNFRSF 21 antibody
    • BM 018 antibody
    • BM018 antibody
    • CD358 antibody
    • Death receptor 6 antibody
    • DR 6 antibody
    • DR6 antibody
    • MGC31965 antibody
    • OTTHUMP00000039915 antibody
    • TNFR related death receptor 6 antibody
    • TNFRSF21 antibody
    • TNFRSF21 protein antibody
    • TNR21_HUMAN antibody
    • Tumor necrosis factor receptor superfamily member 21 antibody
    • Tumor necrosis factor receptor superfamily member 21 precursor antibody
    see all

Anti-DR6 antibody 图像

  • All lanes : Anti-DR6 antibody (ab47180) at 2 µg/ml

    Lane 1 : Total cell lysate from Jurkat cells
    Lane 2 : Total cell lysate from HeLa cells
    Lane 3 : Total cell lysate from Daudi cells

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 72 kDa
    Observed band size : 66 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 33 kDa,36 kDa,60 kDa. We are unsure as to the identity of these extra bands.

Anti-DR6 antibody (ab47180)参考文献

This product has been referenced in:
  • Klíma M  et al. Functional analysis of the posttranslational modifications of the death receptor 6. Biochim Biophys Acta 1793:1579-87 (2009). Read more (PubMed: 19654028) »

See 1 Publication for this product

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