概述

  • 产品名称Anti-DR4抗体
    参阅全部 DR4 一抗
  • 描述
    兔多克隆抗体to DR4
  • 特异性ab69947 detects endogenous levels of total DR4 protein.
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide derived from C terminal of human DR4

  • 阳性对照
    • Extracts from K562, COS7 and RAW264.7 cells.

性能

应用

Our Abpromise guarantee covers the use of ab69947 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 51 kDa (predicted molecular weight: 51 kDa).
ELISA 1/10000.

靶标

  • 功能Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.
  • 组织特异性Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K562 erythroleukemia cells, MCF7 breast carcinoma cells and activated T-cells.
  • 序列相似性Contains 1 death domain.
    Contains 3 TNFR-Cys repeats.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Apo2 antibody
    • CD261 antibody
    • Cytotoxic TRAIL receptor antibody
    • Death receptor 4 antibody
    • DR4 antibody
    • NF related apoptosis-inducing ligand receptor 1 antibody
    • TNF receptor superfamily member 10a antibody
    • TNF-related apoptosis-inducing ligand receptor 1 antibody
    • TNFRSF10A antibody
    • TR10A_HUMAN antibody
    • TRAIL receptor 1 antibody
    • TRAIL-R1 antibody
    • TRAILR 1 antibody
    • TRAILR1 antibody
    • Tumor necrosis factor receptor superfamily member 10A antibody
    • Tumor necrosis factor receptor superfamily member 10a variant 2 antibody
    • Tumor necrosis factor receptor superfamily, member 10a antibody
    see all

Anti-DR4 antibody 图像

  • All lanes : Anti-DR4 antibody (ab69947) at 1/500 dilution

    Lane 1 : K562 cell extract
    Lane 2 : COS7 cell extract
    Lane 3 : RAW264.7 cell extract
    Lane 4 : K562 cell extract with immunising peptide at 10 µg

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 51 kDa
    Observed band size : 51 kDa

Anti-DR4 antibody (ab69947)参考文献

ab69947 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab69947.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"