概述

  • 产品名称Anti-DPM1抗体
    参阅全部 DPM1 一抗
  • 描述
    山羊多克隆抗体to DPM1
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide:

    RELEVRSPRQNKYS

    , corresponding to N terminal amino acids 15-27 of Human DPM1 (NP_003850.1)

  • 阳性对照
    • Human liver lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明Purified from goat serum by ammonium sulphate precipitation, followed by antigen affinity chromatography using the immunizing peptide.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab77541 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ELISA
  • 应用说明ELISA: Use at an assay dependent dilution. Antibody detection limit dilution 1/32000.
    WB: Use at a concentration of 0.1 - 0.3 µg/ml. Predicted molecular weight: 30 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.
    • 通路Protein modification; protein glycosylation.
    • 疾病相关Defects in DPM1 are the cause of congenital disorder of glycosylation type 1E (CDG1E) [MIM:608799]. CDGs are metabolic deficiencies in glycoprotein biosynthesis that usually cause severe mental and psychomotor retardation. They are characterized by under-glycosylated serum glycoproteins. CDG1E is an autosomal recessive disorder, characterized by severe developmental delay, hypotnia, seizures, and dysmorphic features.
    • 序列相似性Belongs to the glycosyltransferase 2 family.
    • 细胞定位Endoplasmic reticulum.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CDGIE antibody
      • dolichol monophosphate mannose synthase antibody
      • Dolichol phosphate mannose synthase antibody
      • Dolichol-phosphate mannose synthase antibody
      • Dolichol-phosphate mannosyltransferase antibody
      • Dolichyl phosphate beta D mannosyltransferase antibody
      • dolichyl phosphate mannosyltransferase polypeptide 1 antibody
      • dolichyl phosphate mannosyltransferase polypeptide 1 catalytic subunit antibody
      • Dolichyl-phosphate beta-D-mannosyltransferase antibody
      • DPM synthase antibody
      • DPM1 antibody
      • DPM1_HUMAN antibody
      • Mannose P dolichol synthase antibody
      • Mannose-P-dolichol synthase antibody
      • MPD synthase antibody
      • MPDS antibody
      see all

    Anti-DPM1 antibody 图像

    • Anti-DPM1 antibody (ab77541) at 0.1 µg/ml + Human liver lysate in RIPA buffer at 35 µg

      Predicted band size : 30 kDa
      Observed band size : 30 kDa

    Anti-DPM1 antibody (ab77541)参考文献

    ab77541 has not yet been referenced specifically in any publications.

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