概述

  • 产品名称
  • 描述
    山羊多克隆抗体to DPM1
  • 经测试应用
    适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide:

    RELEVRSPRQNKYS

    , corresponding to N terminal amino acids 15-27 of Human DPM1 (NP_003850.1)

  • 阳性对照
    • Human liver lysate

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液
    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 纯化说明
    Purified from goat serum by ammonium sulphate precipitation, followed by antigen affinity chromatography using the immunizing peptide.
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab77541 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ELISA
  • 应用说明
    ELISA: Use at an assay dependent dilution. Antibody detection limit dilution 1/32000.
    WB: Use at a concentration of 0.1 - 0.3 µg/ml. Predicted molecular weight: 30 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能
      Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.
    • 通路
      Protein modification; protein glycosylation.
    • 疾病相关
      Defects in DPM1 are the cause of congenital disorder of glycosylation type 1E (CDG1E) [MIM:608799]. CDGs are metabolic deficiencies in glycoprotein biosynthesis that usually cause severe mental and psychomotor retardation. They are characterized by under-glycosylated serum glycoproteins. CDG1E is an autosomal recessive disorder, characterized by severe developmental delay, hypotnia, seizures, and dysmorphic features.
    • 序列相似性
      Belongs to the glycosyltransferase 2 family.
    • 细胞定位
      Endoplasmic reticulum.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CDGIE antibody
      • dolichol monophosphate mannose synthase antibody
      • Dolichol phosphate mannose synthase antibody
      • Dolichol-phosphate mannose synthase antibody
      • Dolichol-phosphate mannosyltransferase antibody
      • Dolichyl phosphate beta D mannosyltransferase antibody
      • dolichyl phosphate mannosyltransferase polypeptide 1 antibody
      • dolichyl phosphate mannosyltransferase polypeptide 1 catalytic subunit antibody
      • Dolichyl-phosphate beta-D-mannosyltransferase antibody
      • DPM synthase antibody
      • DPM1 antibody
      • DPM1_HUMAN antibody
      • Mannose P dolichol synthase antibody
      • Mannose-P-dolichol synthase antibody
      • MPD synthase antibody
      • MPDS antibody
      see all

    图片

    • Anti-DPM1 antibody (ab77541) at 0.1 µg/ml + Human liver lysate in RIPA buffer at 35 µg

      Predicted band size : 30 kDa
      Observed band size : 30 kDa

    实验方案

    文献

    ab77541 has not yet been referenced specifically in any publications.

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    There are currently no Customer reviews or Questions for ab77541.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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