概述

  • 产品名称Anti-DPAGT1抗体
    参阅全部 DPAGT1 一抗
  • 描述
    兔多克隆抗体to DPAGT1
  • 特异性At least four isoforms of DPAGT1 are known to exist; ab117459 will recognize the two longest isoforms. ab117459 is predicted to not cross-react with UHRF1BP1.
  • 经测试应用适用于: WB, ICC/IF, IHC-P, ICCmore details
  • 种属反应性
    与反应: Mouse
    预测可用于: Human
  • 免疫原

    Synthetic peptide corresponding to 17 amino acids within a region near the N terminal of Human DPAGT1 (NP_001373).

  • 阳性对照
    • Mouse kidney tissue lysate.
  • 常规说明Avoid repeated freeze thaw cycles and exposure to prolonged high temperatures.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • 存储溶液Preservative: 0.02% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明ab117459 was purified by affinity chromatography via a peptide column.
  • 克隆多克隆
  • 同种型IgG

应用

Our Abpromise guarantee covers the use of ab117459 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 46 kDa.
ICC/IF Use a concentration of 20 µg/ml.
IHC-P Use at an assay dependent concentration.
ICC Use a concentration of 2.5 µg/ml.

靶标

  • 功能Catalyzes the initial step in the synthesis of dolichol-P-P-oligosaccharides.
  • 通路Protein modification; protein glycosylation.
  • 疾病相关Defects in DPAGT1 are the cause of congenital disorder of glycosylation type 1J (CDG1J) [MIM:608093]. CDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.
  • 序列相似性Belongs to the glycosyltransferase 4 family.
  • 细胞定位Endoplasmic reticulum membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ALG7 antibody
    • AU021132 antibody
    • CDG Ij antibody
    • CDG1J antibody
    • CMS13 antibody
    • CMSTA2 antibody
    • D11S366 antibody
    • DGPT antibody
    • Dolichyl phosphate (UDP N acetylglucosamine) acetylglucosaminephosphotransferase 1 (GlcNAc 1 P transferase) antibody
    • Dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 antibody
    • DPAGT1 antibody
    • DPAGT2 antibody
    • G1PT antibody
    • GlcNAc 1 P transferase 1 antibody
    • GlcNAc-1-P transferase antibody
    • Gnpta antibody
    • GPT antibody
    • GPT_HUMAN antibody
    • H2afx antibody
    • N-acetylglucosamine-1-phosphate transferase antibody
    • UAGT antibody
    • UDP GlcNAc:dolichyl phosphate N acetylglucosaminephosphotransferase antibody
    • UDP N acetylglucosamine dolichyl phosphate N acetylglucosaminephosphotransferase 1 antibody
    • UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase antibody
    • UGAT antibody
    see all

Anti-DPAGT1 antibody 图像

  • Immunofluorescence of DPAGT1 in Human kidney tissue with ab117459 at 20 ug/mL.
  • All lanes : Anti-DPAGT1 antibody (ab117459) at 1 µg/ml

    Lane 1 : Mouse kidney tissue lysate
    Lane 2 : Mouse kidney tissue lysate with blocking peptide

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 46 kDa
  • Immunohistochemical analysis of Human kidney tissue, staining DPAGT1 with ab117459 at 2.5 µg/ml.

Anti-DPAGT1 antibody (ab117459)参考文献

ab117459 has not yet been referenced specifically in any publications.

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