Anti-DPAGT1/GPT抗体(ab117459)
Key features and details
- Rabbit polyclonal to DPAGT1/GPT
- Suitable for: WB
- Reacts with: Mouse
- Isotype: IgG
概述
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产品名称
Anti-DPAGT1/GPT抗体
参阅全部 DPAGT1/GPT 一抗 -
描述
兔多克隆抗体to DPAGT1/GPT -
宿主
Rabbit -
特异性
At least four isoforms of DPAGT1/GPT are known to exist; ab117459 will recognize the two longest isoforms. ab117459 is predicted to not cross-react with UHRF1BP1.
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经测试应用
适用于: WBmore details -
种属反应性
与反应: Mouse -
免疫原
Synthetic peptide corresponding to Human DPAGT1/GPT (N terminal).
Database link: Q9H3H5 -
阳性对照
- WB: Mouse kidney tissue lysate.
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常规说明
Avoid repeated freeze thaw cycles and exposure to prolonged high temperatures.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
存储溶液
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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纯度
Immunogen affinity purified -
纯化说明
ab117459 was purified by affinity chromatography via a peptide column. -
克隆
多克隆 -
同种型
IgG
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab117459于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 46 kDa.
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说明 |
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WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 46 kDa. |
靶标
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功能
Catalyzes the initial step in the synthesis of dolichol-P-P-oligosaccharides. -
通路
Protein modification; protein glycosylation. -
疾病相关
Defects in DPAGT1 are the cause of congenital disorder of glycosylation type 1J (CDG1J) [MIM:608093]. CDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. -
序列相似性
Belongs to the glycosyltransferase 4 family. -
细胞定位
Endoplasmic reticulum membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 13478 Mouse
- SwissProt: P42867 Mouse
- Unigene: 18353 Mouse
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别名
- ALG7 antibody
- AU021132 antibody
- CDG Ij antibody
see all
图片
实验方案
数据表及文件
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Datasheet download
文献 (1)
ab117459 被引用在 1 文献中.
- Tinklenberg JA et al. Myostatin inhibition using mRK35 produces skeletal muscle growth and tubular aggregate formation in wild type and TgACTA1D286G nemaline myopathy mice. Hum Mol Genet 27:638-648 (2018). PubMed: 29293963