Anti-Dopamine Receptor D3抗体(ab125467)

概述

  • 产品名称Anti-Dopamine Receptor D3抗体
    参阅全部 Dopamine Receptor D3 一抗
  • 描述
    兔多克隆抗体to Dopamine Receptor D3
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Rat, Dog, African Green Monkey
  • 免疫原

    Synthetic peptide corresponding to a region within the C terminal amino acids 270-319 (QERGGELKRE EKTRNSLMPL REKKATQMVA IVLGAFIVCW LPFFLTHVLN) of the Human Dopamine Receptor D3 protein (NP_387512).

  • 阳性对照
    • HepG2 cell lysate.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Constituents: 97% PBS, 2% Sucrose
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

相关产品

应用

Our Abpromise guarantee covers the use of ab125467 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 41 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.
  • 组织特异性Brain.
  • 疾病相关Genetic variation in DRD3 is associated with essential tremor hereditary type 1 (ETM1) [MIM:190300]. ETM1 is the most common movement disorder. The main feature is postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant.
  • 序列相似性Belongs to the G-protein coupled receptor 1 family.
  • 翻译后修饰Phosphorylated by GRK4 (GRK4-alpha and GRK4-gamma).
  • 细胞定位Cell membrane. Both membrane-bound and scattered in the cytoplasm during basal conditions. Receptor stimulation results in the rapid internalization and sequestration of the receptors at the perinuclear area (5 and 15 minutes), followed by the dispersal of the receptors to the membrane (30 minutes). DRD3 and GRK4 co-localize in lipid rafts of renal proximal tubule cells.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 3dopamine receptor antibody
    • D antibody
    • D(3) dopamine receptor antibody
    • Dopamine D3 receptor antibody
    • Dopamine receptor D3 antibody
    • DRD3 antibody
    • DRD3_HUMAN antibody
    • ETM1 antibody
    • FET1 antibody
    see all

Anti-Dopamine Receptor D3 antibody 图像

  • Anti-Dopamine Receptor D3 antibody (ab125467) at 1 µg/ml + HepG2 cell lysate at 10 µg

    Predicted band size : 41 kDa

Anti-Dopamine Receptor D3 antibody (ab125467)参考文献

ab125467 has not yet been referenced specifically in any publications.

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