Anti-Dopamine beta Hydroxylase抗体(ab63939)

概述

  • 产品名称Anti-Dopamine beta Hydroxylase抗体
    参阅全部 Dopamine beta Hydroxylase 一抗
  • 描述
    兔多克隆抗体to Dopamine beta Hydroxylase
  • 经测试应用适用于: IHC-P, WB, ELISA, Radioimmunoprecipitation, Inhibition Assaymore details
  • 种属反应性
    与反应: Rat, Guinea pig, Cow, Human
  • 免疫原

    Full length native protein (purified) from bovine adrenal glands

性能

应用

Our Abpromise guarantee covers the use of ab63939 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/2000.
WB 1/2000. Predicted molecular weight: 67 kDa. Pre-incubation with the enzyme abolished staining.
ELISA 1/5000.
Radioimmunoprecipitation Use at an assay dependent concentration.
Inhibition Assay Use at an assay dependent concentration.

靶标

  • 功能Conversion of dopamine to noradrenaline.
  • 通路Catecholamine biosynthesis; (R)-noradrenaline biosynthesis; (R)-noradrenaline from dopamine: step 1/1.
  • 疾病相关Defects in DBH are the cause of dopamine beta-hydroxylase deficiency (DBH deficiency) [MIM:223360]; also known as norepinephrine deficiency or noradrenaline deficiency. This disorder is characterized by profound deficits in autonomic and cardiovascular function, but apparently only subtle signs, if any, of central nervous system dysfunction.
  • 序列相似性Belongs to the copper type II ascorbate-dependent monooxygenase family.
    Contains 1 DOMON domain.
  • 细胞定位Cytoplasmic vesicle > secretory vesicle lumen. Cytoplasmic vesicle > secretory vesicle > chromaffin granule lumen and Cytoplasmic vesicle > secretory vesicle membrane. Cytoplasmic vesicle > secretory vesicle > chromaffin granule membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • dbh antibody
    • DBM antibody
    • Dopamine beta hydroxylase antibody
    • Dopamine beta monooxygenase antibody
    • Dopamine beta-hydroxylase (dopamine beta-monooxygenase) antibody
    • Dopamine beta-monooxygenase antibody
    • DOPO_HUMAN antibody
    • OTTHUMP00000022501 antibody
    • Soluble dopamine beta-hydroxylase antibody
    see all

Anti-Dopamine beta Hydroxylase antibody 图像

  • Immunohistochemical analysis of guinea pig brain stem, staining Dopamine beta Hydroxylase using ab63939 at 1/1000.

Anti-Dopamine beta Hydroxylase antibody (ab63939)参考文献

This product has been referenced in:
  • Zhang J  et al. Adrenergic activation of electrogenic K+ secretion in guinea pig distal colonic epithelium: desensitization via the Y2-neuropeptide receptor. Am J Physiol Gastrointest Liver Physiol 297:G278-91 (2009). IF, IHC ; Guinea pig . Read more (PubMed: 19497958) »

See 1 Publication for this product

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As far as we are aware, specific protocol is not required for this antibody which means any general IHC-P protocol would work. I am sorry to hear that the antibody did not work with your protocol so in order to unders...

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