Anti-Dopamine beta Hydroxylase抗体(ab19353)
Key features and details
- Sheep polyclonal to Dopamine beta Hydroxylase
- Suitable for: ICC/IF, IHC-P
- Reacts with: Rat
- Isotype: n/a
概述
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产品名称
Anti-Dopamine beta Hydroxylase抗体
参阅全部 Dopamine beta Hydroxylase 一抗 -
描述
羊多克隆抗体to Dopamine beta Hydroxylase -
宿主
Sheep -
经测试应用
适用于: ICC/IF, IHC-Pmore details -
种属反应性
与反应: Rat -
免疫原
Synthetic peptide corresponding to Rat Dopamine beta Hydroxylase aa 43-62.
Sequence:SEPPESPFPYHIPLDPEGTL
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常规说明
Detects human, bovine, rat and mouse DBH. It is not effective for immunohistochemistry in human brainThe Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
Preservative: 0.05% Sodium azide -
Concentration information loading...
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纯度
Whole antiserum -
克隆
多克隆 -
研究领域
相关产品
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab19353于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
ICC/IF |
1/5000.
|
|
IHC-P |
1/2000.
|
说明 |
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ICC/IF
1/5000. |
IHC-P
1/2000. |
靶标
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功能
Conversion of dopamine to noradrenaline. -
通路
Catecholamine biosynthesis; (R)-noradrenaline biosynthesis; (R)-noradrenaline from dopamine: step 1/1. -
疾病相关
Defects in DBH are the cause of dopamine beta-hydroxylase deficiency (DBH deficiency) [MIM:223360]; also known as norepinephrine deficiency or noradrenaline deficiency. This disorder is characterized by profound deficits in autonomic and cardiovascular function, but apparently only subtle signs, if any, of central nervous system dysfunction. -
序列相似性
Belongs to the copper type II ascorbate-dependent monooxygenase family.
Contains 1 DOMON domain. -
细胞定位
Cytoplasmic vesicle > secretory vesicle lumen. Cytoplasmic vesicle > secretory vesicle > chromaffin granule lumen and Cytoplasmic vesicle > secretory vesicle membrane. Cytoplasmic vesicle > secretory vesicle > chromaffin granule membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 25699 Rat
- SwissProt: Q05754 Rat
- Unigene: 87166 Rat
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别名
- dbh antibody
- DBM antibody
- Dopamine beta hydroxylase antibody
see all
图片
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (8)
ab19353 被引用在 8 文献中.
- Blokhin V et al. A New Method for the Visualization of Living Dopaminergic Neurons and Prospects for Using It to Develop Targeted Drug Delivery to These Cells. Int J Mol Sci 23:N/A (2022). PubMed: 35409040
- Cui K et al. Restoration of Noradrenergic Function in Parkinson's Disease Model Mice. ASN Neuro 13:17590914211009730 (2021). PubMed: 33940943
- Kim SM et al. Repurposing erectile dysfunction drugs tadalafil and vardenafil to increase bone mass. Proc Natl Acad Sci U S A 117:14386-14394 (2020). PubMed: 32513693
- Luo Z et al. Effect of Electrical Stimulation of Cervical Sympathetic Ganglia on Intraocular Pressure Regulation According to Different Circadian Rhythms in Rats. Invest Ophthalmol Vis Sci 61:40 (2020). PubMed: 32976562
- Underhill SM et al. Amphetamine Stimulates Endocytosis of the Norepinephrine and Neuronal Glutamate Transporters in Cultured Locus Coeruleus Neurons. Neurochem Res 45:1410-1419 (2020). PubMed: 31912366
- Scott AL et al. Regulation of catecholamine release from the adrenal medulla is altered in deer mice (Peromyscus maniculatus) native to high altitudes. Am J Physiol Regul Integr Comp Physiol 317:R407-R417 (2019). PubMed: 31242021
- Mahata SK et al. Effect of heart failure on catecholamine granule morphology and storage in chromaffin cells. J Endocrinol 230:309-23 (2016). PubMed: 27402067
- Talavera-Adame D et al. Enhancement of embryonic stem cell differentiation promoted by avian chorioallantoic membranes. Tissue Eng Part A 15:3193-200 (2009). PubMed: 19364272