Donepezil hydrochloride (ab120763)

概述

  • 产品名称Donepezil hydrochloride
  • 描述
    Acetylcholinesterase inhibitor
  • 生物学描述Potent, selective acetylcholinesterase inhibitor (IC50 = 5.7 nM). Displays >1250 times selectivity for AChE over butyrylcholinesterase. Centrally active. Neuroprotective activity in vitro and in vivo.
  • 纯度> 99%

性能

  • 化学名称2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride
  • 分子量415.96
  • 化学结构Chemical Structure
  • 分子式C24H29NO3.HCl
  • CAS编号120011-70-3
  • 存放说明Store at Room Temperature. The product can be stored for up to 12 months.
  • 溶解度概述Soluble in water to 100 mM
  • 处理

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • 来源

    Synthetic

  • 研究领域

    Donepezil hydrochloride (ab120763)参考文献

    This product has been referenced in:
    • Balducci C  et al. Reversal of visual attention dysfunction after AMPA lesions of the nucleus basalis magnocellularis (NBM) by the cholinesterase inhibitor donepezil and by a 5-HT1A receptor antagonist WAY 100635. Psychopharmacology (Berl) 167:28-36 (2003). Read more (PubMed: 12618916) »
    • Sugimoto H  et al. Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride and related compounds. J Med Chem 38:4821-9 (1995). Read more (PubMed: 7490731) »
    • Ihalainen J  et al. Effects of memantine and donepezil on cortical and hippocampal acetylcholine levels and object recognition memory in rats. Neuropharmacology 61:891-9 (0). Read more (PubMed: 21704049) »

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