概述

  • 产品名称Anti-DOK7抗体
    参阅全部 DOK7 一抗
  • 描述
    兔多克隆抗体to DOK7
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH derived from within residues 400 - 500 of Human DOK7.

    (Peptide available as ab90998.)

  • 阳性对照
    • This antibody gave a positive signal in Human Skeletal Muscle Tissue Lysate.

性能

应用

Our Abpromise guarantee covers the use of ab77371 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Detects a band of approximately 53 kDa (predicted molecular weight: 53 kDa).

靶标

  • 功能Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK.
  • 组织特异性Preferentially expressed in skeletal muscle and heart Present in thigh muscle, diaphragm and heart but not in the liver or spleen (at protein level).
  • 疾病相关Defects in DOK7 are the cause of familial limb-girdle myasthenia autosomal recessive (LGM) [MIM:254300]; also called congenital myasthenic syndrome type 1B or CMS1B. LGM is a congenital myasthenic syndrome characterized by a typical 'limb girdle' pattern of muscle weakness with small, simplified neuromuscular junctions but normal acetylcholine receptor and acetylcholinesterase function.
  • 序列相似性Contains 1 IRS-type PTB domain.
    Contains 1 PH domain.
  • 细胞定位Cell membrane. Cell junction > synapse. Accumulates at neuromuscular junctions.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Docking protein 7 antibody
    • DOK 7 antibody
    • DOK7 antibody
    • DOK7_HUMAN antibody
    • Downstream of tyrosine kinase 7 antibody
    • Protein Dok-7 antibody
    see all

Anti-DOK7 antibody 图像

  • Anti-DOK7 antibody (ab77371) at 1 µg/ml + Human skeletal muscle tissue lysate - total protein (ab29330) at 10 µg

    Secondary
    Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 53 kDa
    Observed band size : 53 kDa
    Additional bands at : 40 kDa. We are unsure as to the identity of these extra bands.

    Exposure time : 2 minutes

Anti-DOK7 antibody (ab77371)参考文献

ab77371 has not yet been referenced specifically in any publications.

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