Anti-DOK6抗体(ab72730)
Key features and details
- Rabbit polyclonal to DOK6
- Suitable for: WB, ICC/IF
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-DOK6抗体 -
描述
兔多克隆抗体to DOK6 -
宿主
Rabbit -
经测试应用
适用于: WB, ICC/IFmore details -
种属反应性
与反应: Human
预测可用于: Mouse -
免疫原
Synthetic peptide derived from an internal sequence within human DOK6.
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阳性对照
- COLO cell extracts. A549 cells.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
存储溶液
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, PBS
Without Mg2+ and Ca2+ -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab72730于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/500 - 1/1000. Detects a band of approximately 38 kDa (predicted molecular weight: 38 kDa).
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ICC/IF |
1/500 - 1/1000.
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说明 |
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WB
1/500 - 1/1000. Detects a band of approximately 38 kDa (predicted molecular weight: 38 kDa). |
ICC/IF
1/500 - 1/1000. |
靶标
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功能
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance. -
组织特异性
Highly expressed in fetal and adult brain. Highly expressed in the cerebellum. Weak expression in kidney, spinal cord and testis. -
序列相似性
Belongs to the DOK family. Type B subfamily.
Contains 1 IRS-type PTB domain.
Contains 1 PH domain. -
结构域
PTB domain mediates receptor interaction. -
翻译后修饰
On Ret activation, phosphorylated on one or more C-terminal tyrosine residues by an Src family kinase. - Information by UniProt
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数据库链接
- Entrez Gene: 220164 Human
- Entrez Gene: 623279 Mouse
- Omim: 611402 Human
- SwissProt: Q6PKX4 Human
- SwissProt: Q2MHE5 Mouse
- Unigene: 278285 Human
- Unigene: 447164 Mouse
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别名
- Docking protein 5 antibody
- Docking protein 5 like antibody
- Docking protein 6 antibody
see all
图片
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All lanes : Anti-DOK6 antibody (ab72730) at 1/500 dilution
Lane 1 : COLO cell extract
Lane 2 : COLO cell extract with immunising peptide at 10 µg
Lysates/proteins at 30 µg per lane.
Predicted band size: 38 kDa
Observed band size: 38 kDa -
ab72730 at 1/500 dilution staining DOK6 in A549 cells by Immunofluorescence, in the absence or presence of the immunising peptide.
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab72730 被引用在 1 文献中.
- Unsworth AJ et al. Antiplatelet properties of Pim kinase inhibition are mediated through disruption of thromboxane A2 receptor signaling. Haematologica 106:1968-1978 (2021). PubMed: 32467143