概述

  • 产品名称Anti-DOK6抗体
    参阅全部 DOK6 一抗
  • 描述
    兔多克隆抗体to DOK6
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Guinea pig, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 281-330 (

    IYSLQGHGFGSSKMSRAQTFPSYAPEQSEEAQQPLSRSSSYGFSYSSSLI

    ) of Human DOK6 (NP_689934).

  • 阳性对照
    • COLO205 cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab102621 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 38 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 相关性DOK6 (docking protein 6) is a novel member of the DOK4/5 subclass of the p62 DOK family of intracellular adaptor molecules. DOK6 is highly expressed in the developing central nervous system and is co expressed with Ret in several locations, including sympathetic, sensory, and parasympathetic ganglia, as well as in the ureteric buds of the developing kidneys. Pull down assays using the DOK6 phosphotyrosine binding (PTB) domain and GDNF activated Ret indicate that DOK6 binds to the phosphorylated Ret Tyr(1062) residue. Moreover, ligand activation of Ret resulted in phosphorylation of tyrosine residue(s) located within the unique C terminus of DOK6 predominantly through a Src dependent mechanism, indicating that DOK6 is a substrate of the Ret Src signaling pathway.
  • 数据库链接
  • 别名
    • Docking protein 5 antibody
    • Docking protein 5 like antibody
    • Docking protein 6 antibody
    • DOK 6 antibody
    • DOK5 antibody
    • DOK5L antibody
    • DOK6 antibody
    • Downstream of tyrosine kinase 6 antibody
    • HsT3226 antibody
    • MGC20785 antibody
    • Protein dok 5 antibody
    see all

Anti-DOK6 antibody 图像

  • Anti-DOK6 antibody (ab102621) at 1 µg/ml + COLO205 cell lysate at 10 µg

    Predicted band size : 38 kDa

Anti-DOK6 antibody (ab102621)参考文献

ab102621 has not yet been referenced specifically in any publications.

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