Anti-DOK5抗体- Carboxyterminal end (ab71767)

概述

  • 产品名称Anti-DOK5抗体- Carboxyterminal end
    参阅全部 DOK5 一抗
  • 描述
    兔多克隆抗体to DOK5 - Carboxyterminal end
  • 经测试应用适用于: ELISA, WB, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Human
  • 阳性对照
    • Mouse liver tissue lysate Human breast carcinoma tissue

性能

应用

Our Abpromise guarantee covers the use of ab71767 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/1000.
WB 1/100 - 1/500. Detects a band of approximately 35 kDa (predicted molecular weight: 35 kDa).
IHC-P 1/50 - 1/100.

靶标

  • 功能DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.
  • 组织特异性Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes.
  • 序列相似性Belongs to the DOK family. Type B subfamily.
    Contains 1 IRS-type PTB domain.
    Contains 1 PH domain.
  • 结构域PTB domain mediates receptor interaction.
  • 翻译后修饰Phosphorylated on tyrosine residues in response to insulin, IGF1 and GDNF.
  • Information by UniProt
  • 数据库链接
  • 别名
    • chromosome 20 open reading frame 180 antibody
    • Docking protein 5 antibody
    • DOK 5 antibody
    • DOK5 antibody
    • DOK5 protein antibody
    • DOK5_HUMAN antibody
    • Downstream of tyrosine kinase 5 antibody
    • Insulin receptor substrate 6 antibody
    • IRS-6 antibody
    • IRS6 antibody
    see all

Anti-DOK5 antibody - Carboxyterminal end 图像

  • Anti-DOK5 antibody - Carboxyterminal end (ab71767) at 1/100 dilution + Mouse liver tissue lysate at 12.5 µg

    Predicted band size : 35 kDa
    Observed band size : 35 kDa
    Additional bands at : 110 kDa,40 kDa,60 kDa,70 kDa,80 kDa. We are unsure as to the identity of these extra bands.
  • Formalin-fixed and paraffin-embedded human breast carcinoma tissue labelled with ab71767 at 1/50 dilution followed by peroxidise conjugation to the secondary antibody and DAB staining.

Anti-DOK5 antibody - Carboxyterminal end (ab71767)参考文献

ab71767 has not yet been referenced specifically in any publications.

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