Anti-DOK5抗体- Aminoterminal end (ab71308)

概述

  • 产品名称Anti-DOK5抗体- Aminoterminal end
    参阅全部 DOK5 一抗
  • 描述
    兔多克隆抗体to DOK5 - Aminoterminal end
  • 经测试应用适用于: WB, IHC-P, ELISAmore details
  • 种属反应性
    与反应: Mouse, Human
  • 阳性对照
    • Mouse liver tissue lysate, human cancer tissue.

性能

应用

Our Abpromise guarantee covers the use of ab71308 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 35 kDa.
IHC-P 1/50 - 1/100.
ELISA 1/1000.

靶标

  • 功能DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.
  • 组织特异性Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes.
  • 序列相似性Belongs to the DOK family. Type B subfamily.
    Contains 1 IRS-type PTB domain.
    Contains 1 PH domain.
  • 结构域PTB domain mediates receptor interaction.
  • 翻译后修饰Phosphorylated on tyrosine residues in response to insulin, IGF1 and GDNF.
  • Information by UniProt
  • 数据库链接
  • 别名
    • chromosome 20 open reading frame 180 antibody
    • Docking protein 5 antibody
    • DOK 5 antibody
    • DOK5 antibody
    • DOK5 protein antibody
    • DOK5_HUMAN antibody
    • Downstream of tyrosine kinase 5 antibody
    • Insulin receptor substrate 6 antibody
    • IRS-6 antibody
    • IRS6 antibody
    see all

Anti-DOK5 antibody - Aminoterminal end 图像

  • Anti-DOK5 antibody - Aminoterminal end (ab71308) at 1/100 dilution + Mouse liver tissue lysate at 12.5 µg

    Predicted band size : 35 kDa
    Observed band size : 30 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 100 kDa,43 kDa,80 kDa. We are unsure as to the identity of these extra bands.
  • Formalin-fixed and paraffin-embedded human breast cancer tissue reacting with ab71308, peroxidase-conjugated secondary used, followed by AEC staining.

Anti-DOK5 antibody - Aminoterminal end (ab71308)参考文献

ab71308 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab71308.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"