概述

  • 产品名称Anti-DOK3抗体
    参阅全部 DOK3 一抗
  • 描述
    山羊多克隆抗体to DOK3
  • 经测试应用适用于: WB, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow
  • 免疫原

    Synthetic peptide:

    TRERRKGPAPCDRP

    , corresponding to C terminal amino acids 484-496 of Human DOK3 (NP_079148.1).

  • 阳性对照
    • Human PBMC lysate; Human placenta and spleen tissues.

性能

应用

Our Abpromise guarantee covers the use of ab118823 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.1 - 0.3 µg/ml. Predicted molecular weight: 53 kDa.
ELISA 1/64000.
IHC-P Use a concentration of 6.13 µg/ml.

靶标

  • 功能DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate Abl function.
  • 组织特异性Expressed in spleen.
  • 序列相似性Belongs to the DOK family. Type A subfamily.
    Contains 1 IRS-type PTB domain.
    Contains 1 PH domain.
  • 结构域PTB domain mediates receptor interaction.
  • 翻译后修饰Constitutively tyrosine-phosphorylated.
    On IL2 stimulation, phosphorylated on C-terminal tyrosine residues possibly by Src kinases. Can also be phosphorylated by ABL kinase.
  • 细胞定位Cytoplasm. Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Docking protein 3 antibody
    • DOK 3 antibody
    • DOK Like Protein antibody
    • Dok3 antibody
    • DOK3_HUMAN antibody
    • DOKL Pending antibody
    • Downstream of tyrosine kinase 3 antibody
    • p62 DOK Like Protein antibody
    see all

Anti-DOK3 antibody 图像

  • Anti-DOK3 antibody (ab118823) at 0.1 µg/ml + Human PBMC lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 53 kDa
  • ab118823, at 6.13 µg/ml, staining DOK3 in formalin fixed, paraffin embedded Human placenta tissue by Immunohistochemistry.
  • ab118823, at 6.13 µg/ml, staining DOK3 in formalin fixed, paraffin embedded Human spleen tissue by Immunohistochemistry.

Anti-DOK3 antibody (ab118823)参考文献

ab118823 has not yet been referenced specifically in any publications.

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