概述

  • 产品名称
  • 描述
    兔多克隆抗体to DOCK4
  • 经测试应用
    适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Cow, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Elephant
  • 免疫原

    Synthetic peptide, corresponding to a region within internal sequence amino acids 1725-1775 of Human DOCK4 (NP_055520.3).

  • 阳性对照
    • Human Ovarian and Prostate Carcinoma tissues.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液
    Preservative: 0.09% Sodium azide
    Constituents: 99% Tris buffered saline, 0.1% BSA
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 纯化说明
    ab111876 is affinity purified using an epitope specific to DOCK4 immobilized on solid support.
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab111876 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能
    Involved in regulation of adherens junction between cells. Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP.
  • 组织特异性
    Widely expressed at low level. Highly expressed in skeletal muscle, prostate and ovary.
  • 序列相似性
    Belongs to the DOCK family.
    Contains 1 DHR-1 (CZH-1) domain.
    Contains 1 DHR-2 (CZH-2) domain.
    Contains 1 SH3 domain.
  • 结构域
    The DHR-2 domain probably mediates the GEF activity.
  • 细胞定位
    Endomembrane system.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Dedicator of cytokinesis protein 4 antibody
    • Dock4 antibody
    • DOCK4_HUMAN antibody
    • KIAA0716 antibody

图片

  • ab111876 at 1/250 dilution staining DOCK4 in Formalin-fixed, Paraffin-embedded Human ovarian carcinoma tissue by Immunohistochemistry. Detection: DAB staining.
  • ab111876 at 1/250 dilution staining DOCK4 in Formalin-fixed, Paraffin-embedded Human Prostate carcinoma tissue by Immunohistochemistry. Detection: DAB staining.

文献

ab111876 has not yet been referenced specifically in any publications.

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