概述

  • 产品名称Anti-DOCK1抗体
    参阅全部 DOCK1 一抗
  • 描述
    兔多克隆抗体to DOCK1
  • 特异性ab92710 detects endogenous levels of total DOCK1 protein.
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    Synthetic peptide derived from an internal region of Human DOCK1.

  • 阳性对照
    • HeLa cell lysate

性能

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应用

Our Abpromise guarantee covers the use of ab92710 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA
WB
  • 应用说明ELISA: 1/40000.
    WB: 1/500 - 1/1000. Predicted molecular weight: 215 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1.
    • 组织特异性Highly expressed in placenta, lung, kidney, pancreas and ovary. Expressed at intermediate level in thymus, testes and colon.
    • 序列相似性Belongs to the DOCK family.
      Contains 1 DHR-1 (CZH-1) domain.
      Contains 1 DHR-2 (CZH-2) domain.
      Contains 1 SH3 domain.
    • 结构域The DHR-2 domain is necessary and sufficient for the GEF activity.
    • 细胞定位Cytoplasm. Membrane. Recruited to membranes via its interaction with phosphatidylinositol 3,4,5-triphosphate.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 180 kDa protein downstream of CRK antibody
      • Ced5 antibody
      • Dedicator of Cytokinesis 1 antibody
      • Dedicator of cytokinesis protein 1 antibody
      • DOCK 1 antibody
      • DOCK 180 antibody
      • DOCK1 antibody
      • DOCK1_HUMAN antibody
      • DOCK180 antibody
      see all

    Anti-DOCK1 antibody 图像

    • All lanes : Anti-DOCK1 antibody (ab92710) at 1/500 dilution

      Lane 1 : HeLa cell lysate
      Lane 2 : HeLa cell lysate with immunizing peptide at 10 µg

      Lysates/proteins at 30 µg per lane.


      Predicted band size : 215 kDa

    Anti-DOCK1 antibody (ab92710)参考文献

    ab92710 has not yet been referenced specifically in any publications.

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