概述

  • 产品名称Anti-DOC2B抗体
    参阅全部 DOC2B 一抗
  • 描述
    兔多克隆抗体to DOC2B
  • 特异性This antibody will label both DOC2B proteins but will not label DOC2A subtype variants. This antibody does not cross react to other calcium binding proteins.
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
    预测可用于: Dog
  • 免疫原

    Synthetic peptide: IGKSNDFIGG VVLGIHAKGE RLKHWFDCLK NKDKRIERWH TLTSELPGAV LSD, corresponding to C terminal amino acids 360-412 of Human DOC2B

  • 常规说明Store undiluted

性能

应用

Our Abpromise guarantee covers the use of ab114864 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500. Predicted molecular weight: 46 kDa.
ELISA 1/10000.

靶标

  • 功能Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes.
  • 组织特异性Widely expressed with highest levels in brain and kidney. Expressed in pancreatic islet cells (at protein level).
  • 序列相似性Contains 2 C2 domains.
  • 结构域C2 domain 1 is involved in binding calcium and phospholipids. C2 domain 2 may also play a role in the calcium-dependent targeting to membranes.
  • 细胞定位Cytoplasm. Cytoplasmic granule. Cell membrane. Translocates to the plasma membrane in a calcium-dependent manner.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Doc2 beta antibody
    • Doc2-beta antibody
    • Doc2b antibody
    • DOC2B_HUMAN antibody
    • DOC2BL antibody
    • Double C2 like domain containing protein beta antibody
    • Double C2 like domains beta antibody
    • Double C2 like domains beta like antibody
    • Double C2-like domain-containing protein beta antibody
    • OTTMUSP00000006522 antibody
    • RP23 78H4.2 antibody
    see all

Anti-DOC2B antibody (ab114864)参考文献

ab114864 has not yet been referenced specifically in any publications.

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