Anti-DNase II抗体(ab115233)

概述

  • 产品名称Anti-DNase II抗体
    参阅全部 DNase II 一抗
  • 描述
    兔多克隆抗体to DNase II
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide: CNGMARKOSRAYKI conjugated to KLH, corresponding to C terminal amino acids 347-360 of Human DNase II.

  • 阳性对照
    • Human thymus and brain cerebellum tissues.

性能

应用

Our Abpromise guarantee covers the use of ab115233 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 40 kDa.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells.
  • 序列相似性Belongs to the DNase II family.
  • 翻译后修饰Glycosylated. Mutations that eliminate N-glycosylation sites reduce activity, but enzymatic deglycosylation has no effect.
  • 细胞定位Lysosome.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Acid DNase antibody
    • Deoxyribonuclease 2 alpha antibody
    • Deoxyribonuclease 2 antibody
    • Deoxyribonuclease II alpha antibody
    • Deoxyribonuclease II antibody
    • Deoxyribonuclease II lysosomal antibody
    • Deoxyribonuclease-2-alpha antibody
    • Deoxyribonuclease2 antibody
    • DeoxyribonucleaseII antibody
    • DNASE 2 antibody
    • DNASE 2A antibody
    • DNase II alpha antibody
    • DNase II lysosomal antibody
    • DNASE2 antibody
    • DNASE2A antibody
    • DNaseII antibody
    • DNL 2 antibody
    • DNL antibody
    • DNL2 antibody
    • DNS2A_HUMAN antibody
    • Lysosomal DNase II antibody
    • R31240 2 antibody
    • R31240_2 antibody
    see all

Anti-DNase II antibody 图像

  • Human thymus tissue (formalin-fixed, paraffin-embedded) stained with ab115233 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody LS-D1, alkaline phosphatase-streptavidin and chromogen.
  • Human cerebellum tissue (formalin-fixed, paraffin-embedded) stained with ab115233 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody LS-D1, alkaline phosphatase-streptavidin and chromogen.

Anti-DNase II antibody (ab115233)参考文献

ab115233 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting Abcam. These antibodies are almost identical and so either would suit your needs. The only difference I can see is that ab8119 does not recognize the 12 kD beta chain, while it is not specified for ab115233. Currently ab115233 ...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"