功能Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm.
序列相似性Contains 1 J domain. Contains 9 TPR repeats.
细胞定位Cytoplasm. Nucleus. Cytoplasm > cytoskeleton. Colocalizes with NR1I3 to microtubules.