概述

  • 产品名称Anti-DNAJC2抗体
    参阅全部 DNAJC2 一抗
  • 描述
    兔多克隆抗体to DNAJC2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a sequence between internal sequence amino acids 233-263 of Human DNAJC2.

  • 阳性对照
    • Mouse Neuro 2a cell line lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab103238 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 72 kDa.

靶标

  • 功能Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'.
  • 组织特异性Widely expressed.
  • 序列相似性Contains 1 J domain.
    Contains 2 SANT domains.
  • 结构域The ZRF1-UBD region specifically recognizes and binds H2AK119ub. The ZRF1-UBD region is also involved in protein-protein interactions with other proteins, suggesting that it may be masked by some regulator, thereby preventing its association with H2AK119ub.
  • 翻译后修饰Phosphorylated in M (mitotic) phase.
  • 细胞定位Nucleus. Cytoplasm > cytosol.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AU020218 antibody
    • DnaJ (Hsp40) homolog subfamily C member 2 antibody
    • DnaJ homolog subfamily C member 2 antibody
    • Dnajc2 antibody
    • DNJC2_HUMAN antibody
    • M phase phosphoprotein 11 antibody
    • M-phase phosphoprotein 11 antibody
    • MGC105894 antibody
    • MIDA1 antibody
    • MPHOSPH11 antibody
    • MPP11 antibody
    • OTTMUSP00000031226 antibody
    • ZRF1 antibody
    • Zrf2 antibody
    • ZUO1 antibody
    • Zuotin related factor 1 antibody
    • Zuotin related factor 2 antibody
    • Zuotin-related factor 1 antibody
    see all

Anti-DNAJC2 antibody 图像

  • Anti-DNAJC2 antibody (ab103238) at 1/100 dilution + Mouse Neuro-2a cell line lysate at 35 µg

    Predicted band size : 72 kDa

Anti-DNAJC2 antibody (ab103238)参考文献

ab103238 has not yet been referenced specifically in any publications.

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