概述

  • 产品名称Anti-DNAH5抗体
    参阅全部 DNAH5 一抗
  • 描述
    兔多克隆抗体to DNAH5
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Pig
  • 免疫原

    N terminal amino acids 54-142 (EVEDAILEGN QIERIDQLFA VGGLRHLMFY YQDVEEAETG QLGSLGGVNL VSGKIKKPKV FVTEGNDVAL TGVCVFFIRT DPSKAITPD) of the Human DNAH5 protein (Q8TE73).

  • 阳性对照
    • Human nasopharynx tissue.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液pH: 7.20
    Preservative: 0.02% Sodium azide
    Constituents: 59% PBS, 40% Glycerol
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab122391 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/1000 - 1/2500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles.
  • 疾病相关Defects in DNAH5 are the cause of primary ciliary dyskinesia type 3 (CILD3) [MIM:608644]. CILD3 is an autosomal recessive disorder characterized by axonemal abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit situs inversus, due to dysfunction of monocilia at the embryonic node and randomization of left-right body asymmetry. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.
    Defects in DNAH5 are a cause of Kartagener syndrome (KTGS) [MIM:244400]. KTGS is an autosomal recessive disorder characterized by the association of primary ciliary dyskinesia with situs inversus. Clinical features include recurrent respiratory infections, bronchiectasis, infertility, and lateral transposition of the viscera of the thorax and abdomen. The situs inversus is most often total, although it can be partial in some cases (isolated dextrocardia or isolated transposition of abdominal viscera).
  • 序列相似性Belongs to the dynein heavy chain family.
  • 结构域Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function.
  • 细胞定位Cytoplasm > cytoskeleton > cilium axoneme.
  • Information by UniProt
  • 数据库链接
  • 别名
    • axonemal antibody
    • Axonemal beta dynein heavy chain 5 antibody
    • Ciliary dynein heavy chain 5 antibody
    • DNAH 5 antibody
    • Dnah5 antibody
    • DNAHC5 antibody
    • DYH5_HUMAN antibody
    • Dynein heavy chain 5 antibody
    • Dynein heavy chain 5, axonemal antibody
    • HL1 antibody
    • KIAA1603 antibody
    see all

Anti-DNAH5 antibody 图像

  • ab122391 at 1/500 staining DNAH5 in parrafin embedded Human nasopharynx tissue using immunohistochemistry.

Anti-DNAH5 antibody (ab122391)参考文献

ab122391 has not yet been referenced specifically in any publications.

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