概述
-
产品名称Anti-DNAH2抗体
-
描述兔多克隆抗体to DNAH2
-
经测试应用适用于: WBmore details
-
种属反应性与反应: Human
-
免疫原
Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 439-468 of Human DNAH2 (NP_065928.2; UniProt Q9P225 isoform 3).
-
阳性对照
- HL60 cell lysate
性能
-
形式Liquid
-
存放说明Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
-
存储溶液Preservative: 0.09% Sodium azide
Constituent: 99% PBS -
Concentration information loading... -
纯度Immunogen affinity purified
-
纯化说明ab123683 is purified through a protein A column, followed by peptide affinity purification.
-
克隆多克隆
-
同种型IgG
-
研究领域
相关产品
-
Compatible Secondaries
应用
Our Abpromise guarantee covers the use of ab123683 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | 1/100 - 1/500. Predicted molecular weight: 100 kDa. |
靶标
-
功能Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly.
-
组织特异性Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in lung.
-
序列相似性Belongs to the dynein heavy chain family.
Contains 5 TPR repeats. -
结构域Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function.
-
细胞定位Cytoplasm > cytoskeleton > cilium axoneme.
- Information by UniProt
-
数据库链接
- Entrez Gene: 146754 Human
- SwissProt: Q9P225 Human
- Unigene: 367649 Human
-
别名
- axonemal antibody
- Axonemal beta dynein heavy chain 2 antibody
- Ciliary dynein heavy chain 2 antibody
see all
Anti-DNAH2 antibody 图像
-
Western blot - Anti-DNAH2 antibody (ab123683)Anti-DNAH2 antibody (ab123683) at 1/100 dilution + HL60 cell lysate at 35 µg
Predicted band size : 100 kDa
Anti-DNAH2 antibody (ab123683)参考文献
ab123683 has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"