概述
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产品名称Anti-DNAH2抗体
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描述兔多克隆抗体to DNAH2
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宿主Rabbit
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经测试应用适用于: WBmore details
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种属反应性与反应: Human
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免疫原
Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 439-468 of Human DNAH2 (NP_065928.2; UniProt Q9P225 isoform 3).
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阳性对照
- HL60 cell lysate
性能
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形式Liquid
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存放说明Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
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存储溶液Preservative: 0.09% Sodium azide
Constituent: 99% PBS -
Concentration information loading... -
纯度Immunogen affinity purified
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纯化说明ab123683 is purified through a protein A column, followed by peptide affinity purification.
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克隆多克隆
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同种型IgG
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研究领域
相关产品
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Compatible Secondaries
应用
Our Abpromise guarantee covers the use of ab123683 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | 1/100 - 1/500. Predicted molecular weight: 100 kDa. |
靶标
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功能Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly.
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组织特异性Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in lung.
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序列相似性Belongs to the dynein heavy chain family.
Contains 5 TPR repeats. -
结构域Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function.
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细胞定位Cytoplasm > cytoskeleton > cilium axoneme.
- Information by UniProt
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数据库链接
- Entrez Gene: 146754 Human
- SwissProt: Q9P225 Human
- Unigene: 367649 Human
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别名
- axonemal antibody
- Axonemal beta dynein heavy chain 2 antibody
- Ciliary dynein heavy chain 2 antibody
see all
图片
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Western blot - Anti-DNAH2 antibody (ab123683)Anti-DNAH2 antibody (ab123683) at 1/100 dilution + HL60 cell lysate at 35 µg
Predicted band size: 100 kDa
文献
ab123683 has not yet been referenced specifically in any publications.
客户评价及客户问答
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"