Anti-DNAH2抗体(ab123683)

概述

• 产品名称Anti-DNAH2抗体
• 描述
  兔多克隆抗体to DNAH2
• 经测试应用适用于: WBmore details
• 种属反应性
  与反应: Human
  
• 免疫原

  Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 439-468 of Human DNAH2 (NP_065928.2; UniProt Q9P225 isoform 3).

• 阳性对照
  • HL60 cell lysate

性能

• 形式Liquid
• 存放说明Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
• 存储溶液Preservative: 0.09% Sodium azide
  Constituent: 99% PBS
• Concentration information loading...
• 纯度Immunogen affinity purified
• 纯化说明ab123683 is purified through a protein A column, followed by peptide affinity purification.
• 克隆多克隆
• 同种型IgG
• 研究领域
  • Signal Transduction
  • Cytoskeleton / ECM
  • Cytoskeleton
  • Motor Proteins
  • Dynein

相关产品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

应用

靶标

• 功能Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly.
• 组织特异性Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in lung.
• 序列相似性Belongs to the dynein heavy chain family.
  Contains 5 TPR repeats.
• 结构域Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function.
• 细胞定位Cytoplasm > cytoskeleton > cilium axoneme.

• Target information above from: UniProt accession Q9P225 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 146754 Human
  • SwissProt: Q9P225 Human
  • Unigene: 367649 Human
• 别名
  • axonemal antibody
  • Axonemal beta dynein heavy chain 2 antibody
  • Ciliary dynein heavy chain 2 antibody

  • Dnah2 antibody
  • DYH2_HUMAN antibody
  • Dynein heavy chain 2 antibody
  • Dynein heavy chain domain-containing protein 3 antibody

  see all