概述

  • 产品名称Anti-DNAH2抗体
  • 描述
    兔多克隆抗体to DNAH2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 439-468 of Human DNAH2 (NP_065928.2; UniProt Q9P225 isoform 3).

  • 阳性对照
    • HL60 cell lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • 存储溶液Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明ab123683 is purified through a protein A column, followed by peptide affinity purification.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab123683 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 100 kDa.

靶标

  • 功能Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly.
  • 组织特异性Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in lung.
  • 序列相似性Belongs to the dynein heavy chain family.
    Contains 5 TPR repeats.
  • 结构域Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function.
  • 细胞定位Cytoplasm > cytoskeleton > cilium axoneme.
  • Information by UniProt
  • 数据库链接
  • 别名
    • axonemal antibody
    • Axonemal beta dynein heavy chain 2 antibody
    • Ciliary dynein heavy chain 2 antibody
    • Dnah2 antibody
    • DYH2_HUMAN antibody
    • Dynein heavy chain 2 antibody
    • Dynein heavy chain domain-containing protein 3 antibody
    see all

Anti-DNAH2 antibody 图像

  • Anti-DNAH2 antibody (ab123683) at 1/100 dilution + HL60 cell lysate at 35 µg

    Predicted band size : 100 kDa

Anti-DNAH2 antibody (ab123683)参考文献

ab123683 has not yet been referenced specifically in any publications.

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