概述

  • 产品名称Anti-DNA Primase抗体
    参阅全部 DNA Primase 一抗
  • 描述
    兔多克隆抗体to DNA Primase
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Purified mouse recombinant p49 subunit of DNA primase.

  • 阳性对照
    • HeLa cells.

性能

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应用

Our Abpromise guarantee covers the use of ab44705 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Detects a band of approximately 49 kDa (predicted molecular weight: 58 kDa).

靶标

  • 相关性DNA primase synthesizes small ribonucleotide primers for the initiation of DNA replication. The eukaryotic primase is a heterodimer of a small and a large subunit, p49 and p58 respectively. These two subunits purify as a complex tightly bound to DNA polymerase alpha. This tight association implicates polymerase alpha as the lagging-strand DNA polymerase in replication. Uniquely, primases are able to synthesize nucleotides de novo on a template by the formation of an initial dinucleotide. DNA primase initiates synthesis with a triphosphate purine moiety at the 5'-end. After synthesis of 7-10 ribonucleotides, the primer template is translocated intramolecularly to the active site of the DNA polymerase alpha subunit. The p49 subunit of DNA primase contains the catalytic active site. The human primase subunits are 90% identical in amino acid sequence to the mouse homologs.
  • 数据库链接
  • 别名
    • dJ422B11.1.1 antibody
    • DNA primase 58kDa subunit antibody
    • DNA primase large subunit antibody
    • DNA primase p58 antibody
    • DNA primase subunit p58 antibody
    • p58 antibody
    • Polypeptide 2A p58 antibody
    • PRIM2 antibody
    • PRIM2A antibody
    • Primase DNA polypeptide 2 (58kDa) antibody
    • Primase polpeptide 2A (58kD) antibody
    • Primase polpeptide 2A 58kDa antibody
    see all

Anti-DNA Primase antibody (ab44705)参考文献

ab44705 has not yet been referenced specifically in any publications.

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