Anti-DNA Polymerase gamma抗体(ab123875)


  • 产品名称Anti-DNA Polymerase gamma抗体
    参阅全部 DNA Polymerase gamma 一抗
  • 描述
    兔多克隆抗体to DNA Polymerase gamma
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse
    预测可用于: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 1119-1148 of Human DNA Polymerase gamma (NP_001119603.1, NP_002684.1).

  • 阳性对照
    • Mouse cerebellum tissue lysate



Our Abpromise guarantee covers the use of ab123875 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 140 kDa.


  • 功能Involved in the replication of mitochondrial DNA.
  • 疾病相关Defects in POLG are the cause of progressive external ophthalmoplegia with mitochondrial DNA deletions autosomal dominant type 1 (PEOA1) [MIM:157640]. Progressive external ophthalmoplegia is characterized by progressive weakness of ocular muscles and levator muscle of the upper eyelid. In a minority of cases, it is associated with skeletal myopathy, which predominantly involves axial or proximal muscles and which causes abnormal fatigability and even permanent muscle weakness. Ragged-red fibers and atrophy are found on muscle biopsy. A large proportion of chronic ophthalmoplegias are associated with other symptoms, leading to a multisystemic pattern of this disease. Additional symptoms are variable, and may include cataracts, hearing loss, sensory axonal neuropathy, ataxia, depression, hypogonadism, and parkinsonism.
    Defects in POLG are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions autosomal recessive (PEOB) [MIM:258450]. PEOB is a severe form of progressive external ophthalmoplegia. It is clinically more heterogeneous than the autosomal dominant forms. Can be more severe.
    Defects in POLG are a cause of sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO) [MIM:607459]. SANDO is a clinically heterogeneous systemic disorder with variable features resulting from mitochondrial dysfunction. It shares phenotypic characteristics with autosomal recessive progressive external ophthalmoplegia and mitochondrial neurogastrointestinal encephalopathy syndrome. The clinical triad of symptoms consists of sensory ataxic, neuropathy, dysarthria, and ophthalmoparesis.
    Defects in POLG are a cause of Alpers-Huttenlocher syndrome (AHS) [MIM:203700]; also called Alpers diffuse degeneration of cerebral gray matter with hepatic cirrhosis. AHS is an autosomal recessive hepatocerebral syndrome. The typical course of AHS includes severe developmental delay, intractable seizures, liver failure, and death in childhood. Refractory seizures, cortical blindness, progressive liver dysfunction, and acute liver failure after exposure to valproic acid are considered diagnostic features. The neuropathological hallmarks of AHS are neuronal loss, spongiform degeneration, and astrocytosis of the visual cortex. Liver biopsy results show steatosis, often progressing to cirrhosis.
    Defects in POLG are a cause of mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE) [MIM:603041]; also known as myoneurogastrointestinal encephalomyopathy. MNGIE is an autosomal recessive disease associated with multiple deletions of skeletal muscle mitochondrial DNA (MtDNA). It is clinically characterized by onset between the second and fifth decades of life, ptosis, progressive external ophthalmoplegia, gastrointestinal dysmotility (often pseudoobstruction), diffuse leukoencephalopathy, thin body habitus, peripheral neuropathy, and myopathy.
    Defects in POLG are a cause of Leigh syndrome (LS) [MIM:256000]. LS is a severe neurological disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions.
  • 序列相似性Belongs to the DNA polymerase type-A family.
  • 细胞定位Mitochondrion.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DNA directed DNA polymerase gamma antibody
    • DNA polymerase subunit gamma 1 antibody
    • DNA polymerase subunit gamma-1 antibody
    • DPOG1_HUMAN antibody
    • MDP 1 antibody
    • MDP1 antibody
    • Mitochondrial DNA polymerase catalytic subunit antibody
    • Mitochondrial DNA polymerase gamma antibody
    • PEO antibody
    • POLG 1 antibody
    • POLG A antibody
    • PolG alpha antibody
    • POLG antibody
    • PolG-alpha antibody
    • POLG1 antibody
    • POLGA antibody
    • Polymerase (DNA directed) gamma antibody
    • SANDO antibody
    • SCAE antibody
    see all

Anti-DNA Polymerase gamma antibody 图像

  • Anti-DNA Polymerase gamma antibody (ab123875) at 1/100 dilution + Mouse cerebellum tissue lysate at 35 µg

    Predicted band size : 140 kDa

Anti-DNA Polymerase gamma antibody (ab123875)参考文献

ab123875 has not yet been referenced specifically in any publications.

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