Anti-DNA PKcs (phospho S2056)抗体- ChIP Grade (ab18192)

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ab18192 被引用在 78 文献中.

  • Wang C  et al. ATM-Deficient Colorectal Cancer Cells Are Sensitive to the PARP Inhibitor Olaparib. Transl Oncol 10:190-196 (2017). WB . PubMed: 28182994
  • Smith EA  et al. DEK is required for homologous recombination repair of DNA breaks. Sci Rep 7:44662 (2017). WB . PubMed: 28317934
  • Natale F  et al. Identification of the elementary structural units of the DNA damage response. Nat Commun 8:15760 (2017). PubMed: 28604675
  • Bot C  et al. Independent mechanisms recruit the cohesin loader protein NIPBL to sites of DNA damage. J Cell Sci 130:1134-1146 (2017). PubMed: 28167679
  • Wald-Altman S  et al. A differential autophagy-dependent response to DNA double-strand breaks in bone marrow mesenchymal stem cells from sporadic ALS patients. Dis Model Mech 10:645-654 (2017). PubMed: 28213588
  • Kim Wiese A  et al. DNA-PKcs controls calcineurin mediated IL-2 production in T lymphocytes. PLoS One 12:e0181608 (2017). PubMed: 28750002
  • Toulany M  et al. Dual targeting of PI3K and MEK enhances the radiation response of K-RAS mutated non-small cell lung cancer. Oncotarget 7:43746-43761 (2016). PubMed: 27248324
  • Couturier AM  et al. Roles for APRIN (PDS5B) in homologous recombination and in ovarian cancer prediction. Nucleic Acids Res 44:10879-10897 (2016). PubMed: 27924011
  • Finzel A  et al. Hyperactivation of ATM upon DNA-PKcs inhibition modulates p53 dynamics and cell fate in response to DNA damage. Mol Biol Cell 27:2360-7 (2016). WB . PubMed: 27280387
  • Vuono EA  et al. The PTEN phosphatase functions cooperatively with the Fanconi anemia proteins in DNA crosslink repair. Sci Rep 6:36439 (2016). ICC/IF ; Human . PubMed: 27819275
  • Harley ME  et al. TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism. Nat Genet 48:36-43 (2016). WB ; Human . PubMed: 26595769
  • Cristini A  et al. DNA-PK triggers histone ubiquitination and signaling in response to DNA double-strand breaks produced during the repair of transcription-blocking topoisomerase I lesions. Nucleic Acids Res 44:1161-78 (2016). WB ; Human . PubMed: 26578593
  • Renaud E  et al. Impaired TIP60-mediated H4K16 acetylation accounts for the aberrant chromatin accumulation of 53BP1 and RAP80 in Fanconi anemia pathway-deficient cells. Nucleic Acids Res 44:648-56 (2016). ICC/IF ; Human . PubMed: 26446986
  • Tadi SK  et al. PAXX Is an Accessory c-NHEJ Factor that Associates with Ku70 and Has Overlapping Functions with XLF. Cell Rep 17:541-555 (2016). PubMed: 27705800
  • Abu-Sanad A  et al. Simultaneous inhibition of ATR and PARP sensitizes colon cancer cell lines to irinotecan. Front Pharmacol 6:147 (2015). WB . PubMed: 26257651
  • Nakahara T  et al. Activation of NF-?B by human papillomavirus 16 E1 limits E1-dependent viral replication through degradation of E1. J Virol 89:5040-59 (2015). PubMed: 25717108
  • Wagner W  et al. L- and D-lactate enhance DNA repair and modulate the resistance of cervical carcinoma cells to anticancer drugs via histone deacetylase inhibition and hydroxycarboxylic acid receptor 1 activation. Cell Commun Signal 13:36 (2015). ICC/IF ; Human . PubMed: 26208712
  • DeLoughery Z  et al. DNA double-strand breaks by Cr(VI) are targeted to euchromatin and cause ATR-dependent phosphorylation of histone H2AX and its ubiquitination. Toxicol Sci 143:54-63 (2015). PubMed: 25288669
  • Wilson JE  et al. Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt. Nat Med N/A:N/A (2015). PubMed: 26107252
  • Burdine LJ  et al. Proteomic Identification of DNA-PK Involvement within the RET Signaling Pathway. PLoS One 10:e0127943 (2015). WB ; Human . PubMed: 26065416
  • Goglia AG  et al. Identification of novel radiosensitizers in a high-throughput, cell-based screen for DSB repair inhibitors. Mol Cancer Ther 14:326-42 (2015). PubMed: 25512618
  • Nakajima NI  et al. Pre-exposure to ionizing radiation stimulates DNA double strand break end resection, promoting the use of homologous recombination repair. PLoS One 10:e0122582 (2015). PubMed: 25826455
  • Maachani UB  et al. Targeting MPS1 Enhances Radiosensitization of Human Glioblastoma by Modulating DNA Repair Proteins. Mol Cancer Res 13:852-62 (2015). PubMed: 25722303
  • Bouley J  et al. A new phosphorylated form of Ku70 identified in resistant leukemic cells confers fast but unfaithful DNA repair in cancer cell lines. Oncotarget 6:27980-8000 (2015). PubMed: 26337656
  • Guo Y  et al. ATM-dependent Phosphorylation of the Fanconi Anemia Protein PALB2 Promotes the DNA Damage Response. J Biol Chem 290:27545-56 (2015). PubMed: 26420486
  • Gustafsson AS  et al. Suppression of DNA-dependent protein kinase sensitize cells to radiation without affecting DSB repair. Mutat Res 769:1-10 (2014). PubMed: 25771720
  • Sahlberg SH  et al. The influence of AKT isoforms on radiation sensitivity and DNA repair in colon cancer cell lines. Tumour Biol 35:3525-34 (2014). WB . PubMed: 24338765
  • Osterman M  et al. Elevated DNA damage response in pancreatic cancer. Histochem Cell Biol 142:713-20 (2014). PubMed: 25002126
  • Zhang B  et al. Mitochondria regulate DNA damage and genomic instability induced by high LET radiation. Life Sci Space Res (Amst) 1:80-88 (2014). PubMed: 25072018
  • Yuan M  et al. RNA binding protein RBM14 promotes radio-resistance in glioblastoma by regulating DNA repair and cell differentiation. Oncotarget 5:2820-6 (2014). WB . PubMed: 24811242
  • Spurlock CF  et al. Methotrexate inhibits NF-?B activity via long intergenic (noncoding) RNA-p21 induction. Arthritis Rheumatol 66:2947-57 (2014). PubMed: 25077978
  • Al-Mashhadi S  et al. Oxidative Glial Cell Damage Associated with White Matter Lesions in the Aging Human Brain. Brain Pathol N/A:N/A (2014). WB ; Human . PubMed: 25311358
  • García CP  et al. Topoisomerase I inhibitor, camptothecin, induces apoptogenic signaling in human embryonic stem cells. Stem Cell Res 12:400-14 (2014). ICC/IF ; Human . PubMed: 24380814
  • Zhou Y  et al. Quantitation of DNA double-strand break resection intermediates in human cells. Nucleic Acids Res 42:e19 (2014). ChIP ; Human . PubMed: 24362840
  • Yu H  et al. Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair. Proc Natl Acad Sci U S A 111:285-90 (2014). PubMed: 24347639
  • Gad H  et al. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature 508:215-21 (2014). PubMed: 24695224
  • Peng M  et al. Crosstalk between BRCA-Fanconi anemia and mismatch repair pathways prevents MSH2-dependent aberrant DNA damage responses. EMBO J N/A:N/A (2014). WB, ICC/IF ; Human . PubMed: 24966277
  • Neal JA  et al. Unraveling the Complexities of DNA-Dependent Protein Kinase Autophosphorylation. Mol Cell Biol 34:2162-75 (2014). WB . PubMed: 24687855
  • Montano R  et al. Sensitization of human cancer cells to gemcitabine by the Chk1 inhibitor MK-8776: cell cycle perturbation and impact of administration schedule in vitro and in vivo. BMC Cancer 13:604 (2013). WB ; Human . PubMed: 24359526
  • Valerie NC  et al. Inhibition of T-type calcium channels disrupts Akt signaling and promotes apoptosis in glioblastoma cells. Biochem Pharmacol 85:888-97 (2013). PubMed: 23287412
  • Calkins AS  et al. DNA damage-induced inhibition of rRNA synthesis by DNA-PK and PARP-1. Nucleic Acids Res 41:7378-86 (2013). PubMed: 23775790
  • Shawi M  et al. Telomerase contributes to fludarabine resistance in primary human leukemic lymphocytes. PLoS One 8:e70428 (2013). Flow Cyt ; Human . PubMed: 23922990
  • Chatterjee P  et al. Defective chromatin recruitment and retention of NHEJ core components in human tumor cells expressing a Cyclin E fragment. Nucleic Acids Res N/A:N/A (2013). PubMed: 24021630
  • Tu WZ  et al. ?H2AX foci formation in the absence of DNA damage: Mitotic H2AX phosphorylation is mediated by the DNA-PKcs/CHK2 pathway. FEBS Lett 587:3437-43 (2013). PubMed: 24021642
  • Yajima H  et al. The complexity of DNA double strand breaks is a critical factor enhancing end-resection. DNA Repair (Amst) 12:936-46 (2013). PubMed: 24041488
  • Boisvert RA  et al. Coordinate Nuclear Targeting of the FANCD2 and FANCI Proteins via a FANCD2 Nuclear Localization Signal. PLoS One 8:e81387 (2013). ICC/IF . PubMed: 24278431
  • Zhou Y & Paull TT DNA-dependent protein kinase regulates DNA end resection in concert with Mre11-Rad50-Nbs1 (MRN) and ataxia telangiectasia-mutated (ATM). J Biol Chem 288:37112-25 (2013). Human . PubMed: 24220101
  • Lundholm L  et al. Resistance to DNA-damaging treatment in non-small cell lung cancer tumor-initiating cells involves reduced DNA-PK/ATM activation and diminished cell cycle arrest. Cell Death Dis 4:e478 (2013). WB ; Human . PubMed: 23370278
  • Žumer K  et al. Unmodified histone H3K4 and DNA-dependent protein kinase recruit autoimmune regulator to target genes. Mol Cell Biol 32:1354-62 (2012). PubMed: 22310661
  • Gandhi M  et al. Homologous chromosomes make contact at the sites of double-strand breaks in genes in somatic G0/G1-phase human cells. Proc Natl Acad Sci U S A 109:9454-9 (2012). PubMed: 22645362
  • Noda A  et al. Unrepairable DNA double-strand breaks that are generated by ionising radiation determine the fate of normal human cells. J Cell Sci 125:5280-7 (2012). PubMed: 22899723
  • Mauro M  et al. p21 promotes error-free replication-coupled DNA double-strand break repair. Nucleic Acids Res 40:8348-60 (2012). WB . PubMed: 22735704
  • Dean JL  et al. Modification of the DNA Damage Response by Therapeutic CDK4/6 Inhibition. J Biol Chem 287:29075-87 (2012). WB . PubMed: 22733811
  • Meek K  et al. N-terminal constraint activates the catalytic subunit of the DNA-dependent protein kinase in the absence of DNA or Ku. Nucleic Acids Res 40:2964-73 (2012). WB . PubMed: 22167471
  • Furusawa Y  et al. DNA double-strand breaks induced by cavitational mechanical effects of ultrasound in cancer cell lines. PLoS One 7:e29012 (2012). ICC/IF ; Human . PubMed: 22235259
  • Kang MA  et al. Deregulation of DNA damage response pathway by intercellular contact. J Biol Chem 287:16246-55 (2012). WB . PubMed: 22431734
  • Bouquet F  et al. A DNA-dependent stress response involving DNA-PK occurs in hypoxic cells and contributes to cellular adaptation to hypoxia. J Cell Sci 124:1943-51 (2011). PubMed: 21576354
  • Lossaint G  et al. Chk1 is dispensable for G2 arrest in response to sustained DNA damage when the ATM/p53/p21 pathway is functional. Oncogene 30:4261-74 (2011). PubMed: 21532626
  • Ogiwara H  et al. Histone acetylation by CBP and p300 at double-strand break sites facilitates SWI/SNF chromatin remodeling and the recruitment of non-homologous end joining factors. Oncogene 30:2135-46 (2011). PubMed: 21217779
  • Adamo A  et al. Preventing nonhomologous end joining suppresses DNA repair defects of Fanconi anemia. Mol Cell 39:25-35 (2010). PubMed: 20598602
  • Du L  et al. Radiosensitization and growth inhibition of cancer cells mediated by an scFv antibody gene against DNA-PKcs in vitro and in vivo. Radiat Oncol 5:70 (2010). PubMed: 20704701
  • Karimi-Busheri F  et al. Senescence evasion by MCF-7 human breast tumor-initiating cells. Breast Cancer Res 12:R31 (2010). WB, IHC . PubMed: 20525204
  • Sakasai R  et al. Proteasome inhibition suppresses DNA-dependent protein kinase activation caused by camptothecin. DNA Repair (Amst) 9:76-82 (2010). PubMed: 19959400
  • Velkova A  et al. Identification of filamin A as a BRCA1-interacting protein required for efficient DNA repair. Cell Cycle 9: (2010). WB ; Human . PubMed: 20305393
  • Shang ZF  et al. Inactivation of DNA-dependent protein kinase leads to spindle disruption and mitotic catastrophe with attenuated checkpoint protein 2 Phosphorylation in response to DNA damage. Cancer Res 70:3657-66 (2010). WB ; Human . PubMed: 20406977
  • Sakasai R  et al. Transcription-dependent activation of ataxia telangiectasia mutated prevents DNA-dependent protein kinase-mediated cell death in response to topoisomerase I poison. J Biol Chem 285:15201-8 (2010). WB ; Human . PubMed: 20304914
  • White JS  et al. Transient ATM kinase inhibition disrupts DNA damage-induced sister chromatid exchange. Sci Signal 3:ra44 (2010). PubMed: 20516478
  • Brugat T  et al. Telomere dysfunction-induced foci arise with the onset of telomeric deletions and complex chromosomal aberrations in resistant chronic lymphocytic leukemia cells. Blood 116:239-49 (2010). ICC/IF ; Human . PubMed: 20424183
  • Zhu H  et al. Involvement of Caveolin-1 in repair of DNA damage through both homologous recombination and non-homologous end joining. PLoS One 5: (2010). WB ; Human . PubMed: 20700465
  • Massip L  et al. Deciphering the chromatin landscape induced around DNA double strand breaks. Cell Cycle 9:2963-72 (2010). ICC/IF, ChIP ; Human . PubMed: 20714222
  • Bensimon A  et al. ATM-dependent and -independent dynamics of the nuclear phosphoproteome after DNA damage. Sci Signal 3:rs3 (2010). WB ; Human . PubMed: 21139141
  • Marston E  et al. Stratification of pediatric ALL by in vitro cellular responses to DNA double-strand breaks provides insight into the molecular mechanisms underlying clinical response. Blood 113:117-26 (2009). WB ; Human . PubMed: 18941120
  • Solier S  et al. Death receptor-induced activation of the Chk2- and histone H2AX-associated DNA damage response pathways. Mol Cell Biol 29:68-82 (2009). WB ; Human . PubMed: 18955500
  • Tsai CY  et al. Targeting DNA repair in chronic lymphocytic leukemia cells with a novel acyclic nucleotide analogue, GS-9219. Clin Cancer Res 15:3760-9 (2009). WB ; Human . PubMed: 19435836
  • Tomimatsu N  et al. Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells. EMBO Rep 10:629-35 (2009). PubMed: 19444312
  • Mordes DA  et al. TopBP1 activates ATR through ATRIP and a PIKK regulatory domain. Genes Dev 22:1478-89 (2008). WB . PubMed: 18519640
  • Willmore E  et al. DNA-Dependent Protein Kinase Is a Therapeutic Target and an Indicator of Poor Prognosis in B-Cell Chronic Lymphocytic Leukemia. Clin Cancer Res 14:3984-3992 (2008). WB, Flow Cyt ; Human . PubMed: 18559621
  • Douglas P  et al. The DNA-dependent protein kinase catalytic subunit is phosphorylated in vivo on threonine 3950, a highly conserved amino acid in the protein kinase domain. Mol Cell Biol 27:1581-91 (2007). WB ; Human . PubMed: 17158925

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