Anti-DMTF1抗体[DMTF5I250] (ab50770)

概述

  • 产品名称Anti-DMTF1抗体[DMTF5I250]
    参阅全部 DMTF1 一抗
  • 描述
    小鼠单克隆抗体[DMTF5I250] to DMTF1
  • 经测试应用适用于: WB, Dot blotmore details
  • 种属反应性
    与反应: Recombinant Fragment
    预测可用于: Human
  • 免疫原

    Recombinant full length protein: ADSPATVDSE TITLNSGTLQ TFEILPSFHL QPTGTPGTYL LQTSSSQGLP LTLTASPTVT LTAAAPASPE QIIVHA (Human)

性能

应用

Our Abpromise guarantee covers the use of ab50770 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent dilution. Predicted molecular weight: 84 kDa.
Dot blot Use at an assay dependent dilution.

靶标

  • 功能Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest (By similarity). Binds to the consensus sequence 5'-CCCG[GT]ATGT-3' (By similarity). Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1.
  • 组织特异性Expressed at relatively low levels in colonic mucosa, ovary, peripheral leukocytes, prostate and small intestine, and at higher levels in spleen, testis and thymus. Expressed in multiple regions of the brain and CNS including amygdala, caudate, corpus callosum, hippocampus, substantia nigra and subthalamic nucleus. Isoform 1 is the predominant isoform in monocytes, macrophages and neutrophils, isoform 2 is most strongly expressed in peripheral blood leukocytes and quiescent CD34 positive cells, and isoform 3 is expressed at low levels in all hematopoietic cell types. Expression is frequently reduced in non-small-cell lung carcinomas (NSCLC) due to hemizygous gene deletion, strongly suggesting that this locus is haploinsufficient for tumor suppression. Loss of this locus frequently occurs in tumors which retain wild-type CDKN2A/ARF and p53/TP53 loci. Hemizygous gene deletion has also been observed in leukemic blasts from patients with abnormalities of the long arm of chromosome 7.
  • 序列相似性Belongs to the DMTF1 family.
    Contains 1 HTH myb-type DNA-binding domain.
    Contains 2 Myb-like domains.
  • 发展阶段Isoform 2 expression is down-regulated during myeloid differentiation, while the expression of isoform 1 and isoform 3 remain constant.
  • 翻译后修饰Phosphorylated by the cyclin-D2/CDK4, cyclin-D3/CDK4 and cyclin-D2/CDK6 complexes and to a lesser extent by the cyclin-D1/CDK4 complex.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Cyclin D binding Myb like protein antibody
    • Cyclin D binding Myb like transcription factor 1 antibody
    • cyclin D binding myb like transcription factor 1D interacting myb like protein antibody
    • Cyclin D interacting Myb like protein 1 antibody
    • Cyclin-D-binding Myb-like transcription factor 1 antibody
    • Cyclin-D-interacting Myb-like protein 1 antibody
    • D interacting myb like protein antibody
    • DMP1 antibody
    • DMTF antibody
    • dmtf1 antibody
    • DMTF1_HUMAN antibody
    • hDMP1 antibody
    • hDMTF1 antibody
    • mDmp1 antibody
    see all

Anti-DMTF1 antibody [DMTF5I250] 图像

Anti-DMTF1 antibody [DMTF5I250] (ab50770)参考文献

ab50770 has not yet been referenced specifically in any publications.

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