概述

  • 产品名称Anti-DMGDH抗体
    参阅全部 DMGDH 一抗
  • 描述
    兔多克隆抗体to DMGDH
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    antigen sequence, corresponding to C terminal amino acids 776-859 (TLATDDVDPE GNESIWYNGK VVGNTTSGSY SYSIQKSLAF AYVPVQLSEV GQQVEVELLG KNYPAVIIQE PLVLTEPTRN RLQK) of Human DMGDH.

  • 阳性对照
    • Human kidney tissue.

性能

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应用

Our Abpromise guarantee covers the use of ab122336 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/20 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 通路Amine and polyamine degradation; betaine degradation; sarcosine from betaine: step 2/2.
  • 疾病相关Defects in DMGDH are the cause of DMGDH deficiency (DMGDHD) [MIM:605850]. DMGDHD is a disorder characterized by fish odor, muscle fatigue with increased serum creatine kinase. Biochemically it is characterized by an increase of N,N-dimethylglycine (DMG) in serum and urine.
  • 序列相似性Belongs to the GcvT family.
  • 细胞定位Mitochondrion.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Dimethylglycine dehydrogenase antibody
    • Dimethylglycine dehydrogenase, mitochondrial antibody
    • Dmgdh antibody
    • M2GD_HUMAN antibody
    • ME2GLYDH antibody
    • mitochondrial antibody
    see all

Anti-DMGDH antibody 图像

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human kidney tissue labelling DMGDH with ab122336. Staining shows strong cytoplasmic positivity in renal tubules.

Anti-DMGDH antibody (ab122336)参考文献

ab122336 has not yet been referenced specifically in any publications.

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