概述

  • 产品名称Anti-DMAP1抗体
    参阅全部 DMAP1 一抗
  • 描述
    兔多克隆抗体to DMAP1
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Rat, Cow, Dog, Human, Chimpanzee
    预测可用于: Chicken
  • 免疫原

    Synthetic peptide corresponding to a region between residues 250 -300 of human DMAP1.

  • 阳性对照
    • Human, mouse and rat brain lysate.

性能

应用

Our Abpromise guarantee covers the use of ab72072 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
IHC-P
  • 应用说明IHC-P: Use at a concentration of 10 µg/ml.
    WB: Use at a concentration of 1 - 4 µg/ml. Detects bands of approximately 27,34 and 53 kDa (predicted molecular weight: 53 kDa).

    The approximately 27 kD band seen in brain lysate is also seen in the prebleed and not thought to be relevant.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 相关性DMAP1 is involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.
    • 细胞定位Nuclear
    • 数据库链接
    • 别名
      • DKFZp686L09142 antibody
      • DMAP 1 antibody
      • DNA methyltransferase 1 associated protein 1 antibody
      • DNMAP 1 antibody
      • DNMAP1 antibody
      • DNMT1 associated protein 1 antibody
      • DNMTAP 1 antibody
      • DNMTAP1 antibody
      • EAF 2 antibody
      • EAF2 antibody
      • FLJ11543 antibody
      • KIAA1425 antibody
      • MAT 1 mediated transcriptional repressor antibody
      • MGC55593 antibody
      • SWC 4 antibody
      • SWC4 antibody
      • zgc:55593 antibody
      see all

    Anti-DMAP1 antibody 图像

    • Lanes 1 - 2 : Anti-DMAP1 antibody (ab72072) at 4 µg/ml
      Lanes 3 - 4 : Anti-DMAP1 antibody (ab72072) at 1 µg/ml

      Lane 1 : human brain lysate
      Lane 2 : human brain lysate plus immunizing peptide
      Lane 3 : mouse brain lysate
      Lane 4 : rat brain lysate


      Predicted band size : 53 kDa
      Observed band size : 53 kDa
      Additional bands at : 27 kDa,34 kDa. We are unsure as to the identity of these extra bands.

    Anti-DMAP1 antibody (ab72072)参考文献

    ab72072 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"