Anti-DMAP1抗体(ab3736)

概述

  • 产品名称Anti-DMAP1抗体
    参阅全部 DMAP1 一抗
  • 描述
    山羊多克隆抗体to DMAP1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Guinea pig, Cow, Dog, Pig, Chimpanzee, Zebrafish, Rhesus monkey, Gorilla, Chinese Hamster, Orangutan, Elephant
  • 免疫原

    Synthetic peptide (Human) - which represented a portion of human DNA methyltransferase 1-associated protein 1 encoded in part by exons 2 and 3.

  • 阳性对照
    • HeLa cell lysate.
  • 常规说明


    Involved in transcription repression. Its interaction with HDAC2 may provide a platform for how histones may become deacetylated in heterochromatin following replication. Can repress transcription independently of histone deacetylase activity.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.1% Sodium Azide
    Constituents: 8mM PBS, 60mM Citrate, 150mM Tris, pH 7-8
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • Primary antibody说明Involved in transcription repression. Its interaction with HDAC2 may provide a platform for how histones may become deacetylated in heterochromatin following replication. Can repress transcription independently of histone deacetylase activity.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab3736 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/5000. Predicted molecular weight: 65 kDa.

靶标

  • 相关性DMAP1 is involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.
  • 细胞定位Nuclear
  • 数据库链接
  • 别名
    • DKFZp686L09142 antibody
    • DMAP 1 antibody
    • DNA methyltransferase 1 associated protein 1 antibody
    • DNMAP 1 antibody
    • DNMAP1 antibody
    • DNMT1 associated protein 1 antibody
    • DNMTAP 1 antibody
    • DNMTAP1 antibody
    • EAF 2 antibody
    • EAF2 antibody
    • FLJ11543 antibody
    • KIAA1425 antibody
    • MAT 1 mediated transcriptional repressor antibody
    • MGC55593 antibody
    • SWC 4 antibody
    • SWC4 antibody
    • zgc:55593 antibody
    see all

Anti-DMAP1 antibody 图像



  • Predicted band size : 65 kDa


    Sample: Hela cell lysate in RIPA buffer (50µg/lane) Antibody: Affinity purified Goat anti-DMAP 1 (ab3736) used at the concentrations indicated. Detection: ECL exposed for 2 minutes.

Anti-DMAP1 antibody (ab3736)参考文献

ab3736 has not yet been referenced specifically in any publications.

Product Wall

We have no clear explanation for the differences in reported mobility of DMAP detected utilizing ab3736, ab3737 and ab2848. The sequences of the peptides used fro ab3736 and ab3737 are proprietary. ab3736 it to a peptide that is toward the N-te...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"