- 数据表
- 具体的参考文献 (2)
- 实验方案
概述
- 产品名称Anti-DLL1抗体
参阅全部 DLL1 一抗 - 描述山羊多克隆抗体to DLL1
- 经测试应用适用于: ICC/IF, WBmore details
- 种属反应性与反应: Mouse, Rat, Human
预测可用于: Chicken, Xenopus laevis, Zebrafish
- 免疫原
Synthetic peptide:
C-ATQRHLTVGEEWSQD
, corresponding to internal sequence amino acids 148-162 of Human DLL1 (NP_005609.3) - 阳性对照
- Mouse Heart and Rat Heart lysates.
性能
- 形式Liquid
- 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
- 存储溶液Preservative: 0.02% Sodium Azide
Constituents: 0.5% BSA, Tris buffered saline, pH 7.3 -
Concentration information loading... - 纯度Immunogen affinity purified
- 纯化说明ab85346 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
- 克隆多克隆
- 同种型IgG
- 研究领域
相关产品
- Compatible Secondaries
应用
Our Abpromise guarantee covers the use of ab85346 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| ICC/IF | Use at an assay dependent concentration. | |
| WB | Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 78 kDa (predicted molecular weight: 78 kDa). |
靶标
- 功能Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor.
- 组织特异性Expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney.
- 序列相似性Contains 1 DSL domain.
Contains 8 EGF-like domains. - 翻译后修饰Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation.
- 细胞定位Membrane.
- Information by UniProt
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数据库链接
- Entrez Gene: 28514 Human
- Entrez Gene: 13388 Mouse
- Entrez Gene: 84010 Rat
- Omim: 606582 Human
- SwissProt: O00548 Human
- SwissProt: Q61483 Mouse
- SwissProt: P97677 Rat
- Unigene: 379912 Human
see all -
别名
- Delta (Drosophila) like 1 antibody
- Delta antibody
- Delta like 1 (Drosophila) antibody
see all
Anti-DLL1 antibody 图像
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Western blot - DLL1 antibody (ab85346)Anti-DLL1 antibody (ab85346) at 0.3 µg/ml + Rat Heart lysate at 35 µg
Predicted band size : 78 kDa
Observed band size : 78 kDa
Anti-DLL1 antibody (ab85346)参考文献
This product has been referenced in:
- Braune EB et al. S/T phosphorylation of DLL1 is required for full ligand activity in vitro but dispensable for DLL1 function in vivo during embryonic patterning and marginal zone B cell development. Mol Cell Biol 34:1221-33 (2014). Read more (PubMed: 24449764) »
- El-Kassar N et al. High levels of IL-7 cause dysregulation of thymocyte development. Int Immunol 24:661-71 (2012). Read more (PubMed: 22899673) »
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"