概述

  • 产品名称Anti-Dkk3抗体
    参阅全部 Dkk3 一抗
  • 描述
    山羊多克隆抗体to Dkk3
  • 经测试应用适用于: WB, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide:

    AAAALLGGEEI

    with a Cysteine residue linker, corresponding to C terminal amino acids 340-350 of Human Dkk3 (NP_037385.2).

  • 阳性对照
    • Human brain cortex tissue; HEK293 lysate.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • 存储溶液pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 99% Tris buffered saline, 0.5% BSA
  • Concentration information loading...
  • 纯度Protein G purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab115869 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.03 - 0.1 µg/ml. Predicted molecular weight: 38 kDa.
ELISA 1/16000.
IHC-P Use a concentration of 5 µg/ml.

靶标

  • 功能Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
  • 组织特异性Highest expression in heart, brain, and spinal cord.
  • 序列相似性Belongs to the dickkopf family.
  • 结构域The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.
  • 翻译后修饰N- and O-glycosylated.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Dickkopf 3 antibody
    • Dickkopf 3 homolog (Xenopus laevis) antibody
    • Dickkopf 3 homolog antibody
    • Dickkopf homolog 3 antibody
    • Dickkopf related protein 3 antibody
    • Dickkopf related protein 3 Precursor antibody
    • Dickkopf WNT signaling pathway inhibitor 3 antibody
    • Dickkopf, Xenopus, homolog of, 3 antibody
    • Dickkopf-3 antibody
    • Dickkopf-related protein 3 antibody
    • Dickkopf3 antibody
    • DKK 3 antibody
    • Dkk-3 antibody
    • DKK3 antibody
    • DKK3_HUMAN antibody
    • hDkk 3 antibody
    • hDkk-3 antibody
    • hDkk3 antibody
    • Regulated in glioma antibody
    • REIC antibody
    • RIG antibody
    • RIG-like 5-6 antibody
    • RIG-like 7-1 antibody
    see all

Anti-Dkk3 antibody 图像

  • ab115869, at 5 µg/ml, staining Dkk3 in Formalin-fixed, Paraffin-embedded Human brain cortex by Immunohistochemistry.
  • Anti-Dkk3 antibody (ab115869) at 2 µg/ml + HEK293 lysate at 30 µg
    Developed using the ECL technique

    Predicted band size : 38 kDa

Anti-Dkk3 antibody (ab115869)参考文献

ab115869 has not yet been referenced specifically in any publications.

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