The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Dickkopf 1 homolog
Dickkopf 1 like
Dickkopf homolog 1
Dickkopf like protein 1
Dickkopf related protein 1
Dickkopf WNT signaling pathway inhibitor 1
Dickkopf-related protein 1
功能Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
序列相似性Belongs to the dickkopf family.
结构域The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.