概述

  • 产品名称Anti-DKK1抗体
    参阅全部 DKK1 一抗
  • 描述
    小鼠单克隆抗体to DKK1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: QPYPCAEDEE CGTDEYCASP TRGGDAGVQI CLACRKRRKR CMRHAMCCPG NYCKNGICVS SDQNHFRGEI EETITESFGN DHSTLDGYSR RTTLSSKMYH , corresponding to amino acids 81-181 of Human DKK1

性能

应用

Our Abpromise guarantee covers the use of ab56905 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
    • 组织特异性Placenta.
    • 序列相似性Belongs to the dickkopf family.
    • 结构域The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.
    • 细胞定位Secreted.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Dickkopf 1 antibody
      • Dickkopf 1 homolog antibody
      • Dickkopf 1 like antibody
      • Dickkopf homolog 1 antibody
      • Dickkopf like protein 1 antibody
      • Dickkopf related protein 1 antibody
      • Dickkopf WNT signaling pathway inhibitor 1 antibody
      • Dickkopf-1 antibody
      • Dickkopf-related protein 1 antibody
      • DKK 1 antibody
      • Dkk-1 antibody
      • Dkk1 antibody
      • DKK1_HUMAN antibody
      • hDkk 1 antibody
      • hDkk-1 antibody
      • SK antibody
      see all

    Anti-DKK1 antibody 图像



    • Predicted band size : 29 kDa
      DKK1 antibody (ab56905) at 1ug/lane + HeLa cell lysate at 25ug/lane.

    Anti-DKK1 antibody (ab56905)参考文献

    ab56905 has not yet been referenced specifically in any publications.

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