概述

  • 产品名称Anti-DISP2抗体
    参阅全部 DISP2 一抗
  • 描述
    兔多克隆抗体to DISP2
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    N-Terminus of Human DISP2

  • 阳性对照
    • Human Small Intestine tissue.

性能

应用

Our Abpromise guarantee covers the use of ab113837 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use a concentration of 5 µg/ml.

靶标

  • 相关性DISP2 is the second of three known homologs of the D.melanogaster protein Dispatched. It is a multitransmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored Hedgehog from producing cells. Hedgehog is a major player in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis and the DISP proteins have been implicated in these pathways. Recently, it has been shown that DISP2 is translationally regulated by the microRNA miR-214 in zebrafish. Expression of this miRNA decreased DISP2 promoter activity in vitro and its overexpression in zebrafish resulted in a phenotype identical to that observed by DISP2 mutants. At least two isoforms of DISP2 are known to exist.
  • 细胞定位Membrane; Multi-pass membrane protein.
  • 数据库链接
  • 别名
    • DISP 2 antibody
    • Dispatched B antibody
    • Dispatched homolog 2 (Drosophila) antibody
    • Dispatched homolog 2 antibody
    • DISPB antibody
    • DKFZp547N223 antibody
    • HsT16908 antibody
    • KIAA1742 antibody
    • Protein dispatched homolog 2 antibody
    see all

Anti-DISP2 antibody 图像

  • ab113837, at 5µg/ml, staining DISP2 in formalin-fixed, paraffin-embedded Human Small Intestine tissue by Immunohistochemistry.

Anti-DISP2 antibody (ab113837)参考文献

ab113837 has not yet been referenced specifically in any publications.

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