概述

  • 产品名称
  • 描述
    山羊多克隆抗体to DIS
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Rat
    预测可用于: Cow, Dog, Human, Pig
  • 免疫原

    Synthetic peptide:

    RYCKERPSKDKE

    , corresponding to internal sequence (near C-Terminus) amino acids 901-912 of Human DIS (NP_060707.2).

  • 阳性对照
    • Mouse and Rat skeletal muscle lysates

性能

应用

Our Abpromise guarantee covers the use of ab99282 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 120 kDa (predicted molecular weight: 133 kDa). An approximately 120 kDa band was observed in Mouse and Rat Skeletal Muscle lysates. An additional band of unknown identity was also consistently observed at 33 kDa. This band was successfully blocked by incubation with the immunizing peptide.

靶标

  • 功能
    Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation.
  • 组织特异性
    Expressed in various epithelial cancer cell lines, including breast, colon, prostate, pancreatic and leukemia. Expression is regulated by growth factors.
  • 序列相似性
    Contains 1 SAP domain.
  • 翻译后修饰
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位
    Cytoplasm > perinuclear region.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CARP-1 antibody
    • Carp1 antibody
    • Ccar1 antibody
    • CCAR1_HUMAN antibody
    • Cell cycle and apoptosis regulatory protein 1 antibody
    • cell division cycle and apoptosis regulator 1 antibody
    • Cell division cycle and apoptosis regulator protein 1 antibody
    • Death inducer with SAP domain antibody
    • FLJ10590 antibody
    • FLJ10839 antibody
    • FLJ13376 antibody
    • FLJ20734 antibody
    • MGC7730 antibody
    • RP11-437A18.1 antibody
    see all

图片

  • Anti-DIS antibody (ab99282) at 1 µg/ml + Rat skeletal muscle lysate in RIPA buffer at 35 µg
    Developed using the ECL technique

    Predicted band size : 133 kDa

实验方案

文献

ab99282 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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