概述

  • 产品名称Anti-DIP13B抗体
    参阅全部 DIP13B 一抗
  • 描述
    兔多克隆抗体to DIP13B
  • 经测试应用适用于: WB, ELISA, ICC/IFmore details
  • 种属反应性
    与反应: Mouse, Rat, Human, Monkey
  • 免疫原

    Recombinant full-length Human DIP13B expressed in E. coli cells

  • 阳性对照
    • HEK293 cell line lysate. MDA-MB-231 cell line lysate. C2C12 cells

性能

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应用

Our Abpromise guarantee covers the use of ab95196 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.2 - 0.3 µg/ml. Detects a band of approximately 75 kDa (predicted molecular weight: 74 kDa).
ELISA Use a concentration of 1 - 2 µg/ml.
ICC/IF Use a concentration of 2 - 3 µg/ml.

靶标

  • 功能Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction.
  • 组织特异性High levels in brain, heart, kidney and skeletal muscle.
  • 疾病相关Note=A chromosomal aberration involving APPL2/DIP13B is found in patients with chromosome 22q13.3 deletion syndrome. Translocation t(12;22)(q24.1;q13.3) with SHANK3/PSAP2.
  • 序列相似性Contains 1 PH domain.
    Contains 1 PID domain.
  • 细胞定位Early endosome membrane. Nucleus. Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Adapter protein containing PH domain antibody
    • Adapter protein containing PH domain PTB domain and leucine zipper motif 2 antibody
    • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 antibody
    • APLP2 antibody
    • Appl2 antibody
    • DCC interacting protein 13 beta antibody
    • DCC-interacting protein 13-beta antibody
    • Dip13 beta antibody
    • Dip13-beta antibody
    • DP13B_HUMAN antibody
    • PTB domain and leucine zipper motif 2 antibody
    see all

Anti-DIP13B antibody 图像

  • All lanes : Anti-DIP13B antibody (ab95196) at 0.2 µg/ml

    Lane 1 : HEK293 cell lysate
    Lane 2 : MDA-MB-231 cell lysate

    Lysates/proteins at 20 µg per lane.

    Secondary
    Goat anti-rabbit antibody

    Predicted band size : 74 kDa
  • ab95196, at 2 µg/ml, staining DIP13B in C2C12 cells Immunocytochemistry visualised by confocal microscopy.

Anti-DIP13B antibody (ab95196)参考文献

ab95196 has not yet been referenced specifically in any publications.

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