概述

  • 产品名称Anti-Dio3抗体
    参阅全部 Dio3 一抗
  • 描述
    兔多克隆抗体to Dio3
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Rat
    预测可用于: Human
  • 免疫原

    Synthetic peptide corresponding to a region within internal residues 250-300 of Rat Dio3.

  • 阳性对照
    • Rat placenta lysate.

性能

应用

Our Abpromise guarantee covers the use of ab82041 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.5 µg/ml. Detects a band of approximately 31 kDa (predicted molecular weight: 31 kDa).

靶标

  • 功能Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development.
  • 组织特异性Expressed in placenta and several fetal tissues.
  • 序列相似性Belongs to the iodothyronine deiodinase family.
  • 细胞定位Cell membrane. Endosome membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 5DIII antibody
    • D3 antibody
    • Deiodinase iodothyronine type 3 antibody
    • Deiodinase iodothyronine type III antibody
    • Dio 3 antibody
    • Dio3 antibody
    • DIOIII antibody
    • IOD3_HUMAN antibody
    • Iodothyronine deiodinase placental type antibody
    • MGC124117 antibody
    • MGC124118 antibody
    • Thyroxine deiodinase type III antibody
    • Thyroxine deiodinase type III (selenoprotein) antibody
    • TXDI3 antibody
    • Type 3 DI antibody
    • Type 3 iodothyronine selenodeiodinase antibody
    • Type III 5' deiodinase antibody
    • Type III iodothyronine deiodinase antibody
    • Type-III 5''-deiodinase antibody
    see all

Anti-Dio3 antibody 图像

  • Anti-Dio3 antibody (ab82041) at 0.5 µg/ml + rat placenta lysate

    Predicted band size : 31 kDa
    Observed band size : 31 kDa

Anti-Dio3 antibody (ab82041)参考文献

This product has been referenced in:
  • Bedolla DE & Torre V A component of retinal light adaptation mediated by the thyroid hormone cascade. PLoS One 6:e26334 (2011). WB ; Rat . Read more (PubMed: 22039463) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"