概述

  • 产品名称
  • 描述
    兔多克隆抗体to DHX58
  • 经测试应用
    适用于: WB, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Rat, Human
    预测可用于: Mouse
  • 免疫原

    Synthetic peptide corresponding to 11 internal sequence amino acids of Human DHX58 (NP_077024.2).

  • 阳性对照
    • Rat kidney tissue lysate; Human Brain, Cortex tissue.

性能

应用

Our Abpromise guarantee covers the use of ab115674 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 77 kDa.
ELISA Use at an assay dependent concentration.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能
    Participates in innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, triggers a transduction cascade which results in the induction and expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). The RNA helicase domain may recognize and structurally modify viral RNA to facilitate detection by DDX58/RIG-I or by IFIH1/MDA5 whose affinity for dsRNA is lower.
  • 序列相似性
    Belongs to the helicase family.
    Contains 1 helicase ATP-binding domain.
    Contains 1 helicase C-terminal domain.
  • 细胞定位
    Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • D11LGP2 antibody
    • D11lgp2e antibody
    • DEXH (Asp Glu X His) box polypeptide 58 antibody
    • DEXH box polypeptide 58 antibody
    • DHX 58 antibody
    • DHX58 antibody
    • DHX58_HUMAN antibody
    • LGP 2 antibody
    • LGP2 antibody
    • Ortholog of mouse D11lgp2 antibody
    • Probable ATP dependent helicase LGP2 antibody
    • Probable ATP dependent RNA helicase DHX58 antibody
    • Probable ATP-dependent helicase LGP2 antibody
    • Probable ATP-dependent RNA helicase DHX58 antibody
    • Protein D11Lgp2 homolog antibody
    • RIG-I-like receptor LGP2 antibody
    • RLR antibody
    • RNA helicase LGP2 antibody
    see all

图片

  • Lane 1 : Anti-DHX58 antibody (ab115674) at 1 µg/ml
    Lane 2 : Anti-DHX58 antibody (ab115674) at 2 µg/ml

    Lane 1 : Rat kidney tissue lysate
    Lane 2 : Rat kidney tissue lysate


    Predicted band size : 77 kDa
  • ab115674, at 5µg/ml, staining DHX58 in Formalin-fixed, Paraffin-embedded Human Brain cortex tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

文献

ab115674 has not yet been referenced specifically in any publications.

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