Anti-Dhh抗体[RM0086-6A12] (ab86061)

概述

  • 产品名称
    Anti-Dhh抗体[RM0086-6A12]
    参阅全部 Dhh 一抗
  • 描述
    大鼠单克隆抗体[RM0086-6A12] to Dhh
  • 特异性
    ab86061 detects Mouse Dhh N terminal polypeptide, but not C terminal polypeptide.
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Mouse recombinant Dhh N-terminal fragment

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液
    Preservative: None
    Constituents: PBS
  • Concentration information loading...
  • 纯度
    Protein A purified
  • 纯化说明
    The IgG fraction of culture supernatant was purified by Protein A/G affinity chromatography and filter sterilized through a 0.2 µm filter.
  • 克隆
    单克隆
  • 克隆编号
    RM0086-6A12
  • 同种型
    IgG2
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab86061 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明
    WB: 1/500 - 1/1000. Predicted molecular weight: Unprocessed precursor, 44 kDa; Dhh protein N-product, 20 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能
      Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development.
    • 疾病相关
      Defects in DHH may be the cause of partial gonadal dysgenesis with minifascicular neuropathy 46,XY (PGD) [MIM:607080]. PGD is characterized by the presence of a testis on one side and a streak or an absent gonad at the other, persistence of Muellerian duct structures, and a variable degree of genital ambiguity.
      Defects in DHH may be the cause of complete pure gonadal dysgenesis 46,XY type (GDXYM) [MIM:233420]; also known as male-limited gonadal dysgenesis 46,XY. GDXYM is a type of hypogonadism in which no functional gonads are present to induce puberty in an externally female person whose karyotype is then found to be XY. The gonads are found to be non-functional streaks.
    • 序列相似性
      Belongs to the hedgehog family.
    • 翻译后修饰
      The C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity. Both activities result in the cleavage of the full-length protein and covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-terminal fragment (N-product). This covalent modification appears to play an essential role in restricting the spatial distribution of the protein activity to the cell surface. The N-product is the active species in both local and long-range signaling, whereas the C-product has no signaling activity.
    • 细胞定位
      Secreted > extracellular space. The C-terminal peptide diffuses from the cell and Cell membrane. The N-terminal peptide remains associated with the cell surface.
    • Information by UniProt
    • 数据库链接
    • 别名
      • C78960 antibody
      • Desert hedgehog (Drosophila) homolog antibody
      • Desert hedgehog antibody
      • Desert hedgehog homolog (Drosophila) antibody
      • Desert hedgehog protein C-product antibody
      • Desert hedgehog protein precursor antibody
      • DHH antibody
      • DHH_HUMAN antibody
      • GDXYM antibody
      • HHG-3 antibody
      • Hira antibody
      • SRXY7 antibody
      see all

    实验方案

    Anti-Dhh antibody [RM0086-6A12] (ab86061)参考文献

    ab86061 has not yet been referenced specifically in any publications.

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