Anti-Dhh抗体(ab97287)

概述

  • 产品名称Anti-Dhh抗体
    参阅全部 Dhh 一抗
  • 描述
    兔多克隆抗体to Dhh
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Recombinant protein fragment containing a sequence corresponding to a region within amino acids 135-388 of Human Dhh (NP_066382)

  • 阳性对照
    • 293T; Jurkat or Raji lysates and A431 whole cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab97287 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 44 kDa.

靶标

  • 功能Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development.
  • 疾病相关Defects in DHH may be the cause of partial gonadal dysgenesis with minifascicular neuropathy 46,XY (PGD) [MIM:607080]. PGD is characterized by the presence of a testis on one side and a streak or an absent gonad at the other, persistence of Muellerian duct structures, and a variable degree of genital ambiguity.
    Defects in DHH may be the cause of complete pure gonadal dysgenesis 46,XY type (GDXYM) [MIM:233420]; also known as male-limited gonadal dysgenesis 46,XY. GDXYM is a type of hypogonadism in which no functional gonads are present to induce puberty in an externally female person whose karyotype is then found to be XY. The gonads are found to be non-functional streaks.
  • 序列相似性Belongs to the hedgehog family.
  • 翻译后修饰The C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity. Both activities result in the cleavage of the full-length protein and covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-terminal fragment (N-product). This covalent modification appears to play an essential role in restricting the spatial distribution of the protein activity to the cell surface. The N-product is the active species in both local and long-range signaling, whereas the C-product has no signaling activity.
  • 细胞定位Secreted > extracellular space. The C-terminal peptide diffuses from the cell and Cell membrane. The N-terminal peptide remains associated with the cell surface.
  • Information by UniProt
  • 数据库链接
  • 别名
    • C78960 antibody
    • Desert hedgehog (Drosophila) homolog antibody
    • Desert hedgehog antibody
    • Desert hedgehog homolog (Drosophila) antibody
    • Desert hedgehog protein C-product antibody
    • Desert hedgehog protein precursor antibody
    • DHH antibody
    • DHH_HUMAN antibody
    • GDXYM antibody
    • HHG-3 antibody
    • Hira antibody
    • SRXY7 antibody
    see all

Anti-Dhh antibody 图像

  • Anti-Dhh antibody (ab97287) at 1/10000 dilution + A431 whole cell lysate at 30 µg

    Predicted band size : 44 kDa

Anti-Dhh antibody (ab97287)参考文献

ab97287 has not yet been referenced specifically in any publications.

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